腦缺血再灌注不同階段的損傷機(jī)制及中藥干預(yù)作用

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[關(guān)鍵詞]腦缺血再灌注；中藥；中藥單體；中藥復(fù)方；發(fā)病機(jī)制；作用機(jī)制 [中圖分類號(hào)]R255.2 [文獻(xiàn)標(biāo)志碼]A [文章編號(hào)]doi：10.3969/j.issn.1674-070X.2025.06.029

Injury mechanisms at different stages of cerebral ischemia-reperfusion and the interventional effects of Chinese medicines

ZHOU Xin'，LI Lan'， FU Ziyu’， OUYANG Linqi'，HU Hua’， CHEN Zhen’， DENG Guiming I，2： ￥ 1.The First Hospital of Hunan University of Chinese Medicine，Changsha， Hunan 41Ooo7，China; 2.The Second Hospital of Hunan University of Chinese Medicine，Changsha， Hunan 41ooo5，China

[Abstract]Cerebralischemia-reperfusioninjury（CIRI），acommoncomplicationfollowingstroke，ischaracterizedbycomplex pathogenesisandpoorclinicalprognosis.CIRIcanbedividedintothreephases：acuteischemiaearlyreperfusion，andlate reperfusionEachphaseexhibitsdistinctyetinterconnectedinjurymechanismsthatcolectivelyacceleratediseaseprogession， ultimatelyleading toirreversiblebraindamage.Theacuteischemicphaseisdominatedbyenergymetabolismdysfunctioand calciumoverload;theearlyreperfusionphaseismarkedbysevereoxidativestressandinflammatoryresponses;whilethelate reperfusionphaseinvolvesferroptosisandimpairedneurogenesis，contributingtoieversiblebraintissedamage.Chinese medicines demonstratesuniqueadvantages intreating CIRIbyexertingsynergisticefectsthroughmultiplepathwaysandtargets， suchasantioxidantstress，inhibitinginflammatoryresponses，protectingmitochondrialfunction，andregulatingcalciumion homeostasis，therebycomprehensivelyameliorating thepathologicalprocessofCIRIThispapersystematicallyreviewstephased injurymechanismsofCRIandsummarizestheexperimentalresearchprogressofChinesemedicinesinterventionsinIIaiming to providenew insights for the mechanistic studyand clinical translation of Chinese medicines in treating CIRI.

[Keywords]cerebral ischemia-reperfusion;Chinese medicines; Chinese medicine monomer;Chinese medicinecompound; ）athogenesis;mechanism of action

腦缺血再灌注損傷（cerebral ischemia-reperfu-sion injury，CIRI）是指在缺血性腦卒中后，血流和氧氣供應(yīng)恢復(fù)，神經(jīng)細(xì)胞結(jié)構(gòu)和功能進(jìn)一步受損的病理過(guò)程[]。（剩余17534字）