神經(jīng)肽參與調(diào)控神經(jīng)病理性疼痛機(jī)制的研究進(jìn)展

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[Abstract]Thepathological mechanismsoforofacial neuropathic painarecomplex.Currntly，the lackoflong-lasting andefectiveclinical treatmentdrugsgreatlyburdens thelivesofpatients.Neuropeptides，includinggalanin，calcitonin gene-related peptide，neuropeptideY，ndoxytocin，amongothers，canegulate nociceptivetransmissionthroughieent signalingpathways，thus playingacrucialrole inthepathological processesofneuropathicpain.At present，theroleand mechanismofneuropeptides inorofacialneuropathicpainareelativelyinsuicient，andthereisalackofsuficientclinicalevidenceregarding neuropeptides as therapeutic targets fororofacialneuropathicpain.Thisarticle summarizes mechanisms ofneuropeptidesin theperipheral andcentral nervous systems to provide new ideas for exploring their role and mechanisms inorofacial neuropathic pain，and to recommend effective strategies fordeveloping newanalgesic drugs.

[Key words]neuropeptides；orofacial neuropathic pain；central nervous system；peripheral nervous system；signaling pathways

根據(jù)國際疼痛研究協(xié)會（InternationalAssocia-tionfortheStudyofPain，IASP）的定義，疼痛是一種與實際或潛在組織損傷或與這類損傷描述相關(guān)的不愉快的感覺和情感經(jīng)歷[]。（剩余22349字）