宏基因組高通量測序輔助診斷日本斑點熱一例

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中圖分類號：R513.3 文獻標識碼：B 文章編號：1000-503X（2025）01-0146-04

DOI：10.3881/j. issn.1000-503X.15997

Metagenomic Next- Generation Sequencing- Assisted Diagnosis of Japanese Spotted Fever ： Report of One Case

RUAN Yongchun1，ZHOU Yiqing'，ZHANG Haiwang'，ZHOU Jie 1 ，DUAN Jinnan1ZHANG Xiaojing2，LI Minghui'

1 Department of Infectious Diseases，Shaoxing People’s Hospital，Shaoxing，Zhejiang 312Oo，China （20 2 WilingMed Technology（Beijing）Company Limited，Beijing 10023，China

Correspondingauthor：LI Minghui Tel：0575-88559192，E-mail：lmhhx@163.com

ABSTRACT： Japanese spotted fever（JSF） is an infectious disease caused by Rickettsia japonica， with nonspecific clinical symptoms and a high risk of misdiagnosis.We reported acase of JSF，in which Ricketsia japonica was detected in blood cels by metagenomic next- generation sequencing.The patient recovered after treatment with doxycycline.This report provides a reference for the clinical diagnosis and treatment of JSF.

Keywords：Ricketsia japonica；Japanese spotted fever；diagnosis；metagenomicnext-generationsequencing

ActaAcadMedSin，2025，47（1）：146-149

日本斑點熱（Japanesespottedfever，JSF）是經(jīng)蜱蟲叮咬傳播的一種自然疫源性疾病，于1984年首次在日本發(fā)現(xiàn)并報道，后其病原體被建議命名為日本立克次體[1-2]，常見于山區(qū)居民和農(nóng)民，以散發(fā)為主，但也有社區(qū)聚集的案例報道[3]。（剩余8205字）