代謝相關(guān)疾病與草酸鈣結(jié)石形成機制的研究進展

中圖分類號：R692.4文獻標識碼：A 文章編號：1000-503X（2025）01-0124-07

DOI：10.3881/j. issn. 1000-503X.16038

Research Progress in Metabolism-Related Diseases and Formation Mechanism of Calcium Oxalate Stones

CEN Weihu1， SHEN Jun1.2， XIA Shashal， WANG Qiang1

（204號 1 Department of Urology，The Affiliated Hospital of Guizhou Medical University，Guiyang 55ooo0，China （20 2 Departmentof Urology，Guizhou Hospital，TheFirstAffliated Hospitalof SunYat-sen University，Guiyang 550o，China

Corresponding author：SHENJunTel：13628568909，E-mail：shenjun@gmc.edu.cn

ABSTRACT： Kidney stones are a urinary system disease with a high incidence， among which calcium oxalate stones are the most common.Metabolic disorders such as hypertension，diabetes，obesity，hyperlipidemia，and hyperuricemia can cause changes in oxalate，uricacid，and pH and calcium ion concentrations in the urine through multiple pathways including inducing oxidative stress and inflammatory responses by generating reactive oxygen species，ultimately affcting the formation of calcium oxalate stones.This article reviews the possible pathways and mechanisms by which metabolic diseases influence the formation of calcium oxalate stones， providing new ideas for the clinical prevention and treatment of calcium oxalate stones.

Key words：calcium oxalate stone；metabolism-related diseases；mechanism；reactive oxygen species

ActaAcadMedSin，2025，47（1）：124-130

腎結(jié)石在全球范圍內(nèi)的患病率和發(fā)病率呈上升趨勢[1]，5年內(nèi)的復發(fā)率約為 50% ，其中草酸鈣結(jié)石為最常見的類型。（剩余15433字）