銅穩(wěn)態(tài)與疾病研究進展

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中圖分類號：R13 文獻標識碼：A 文章編號：1000-503X（2025）01-0102-08

DOI：10.3881/j.issn.1000-503X.15884

Research Progress in Copper Homeostasis and Diseases

QIU Shuting1，TAN Xiaohua1， SHAO Shihan1，LI Yu1 ， ZHANG Yingying1， CAO Yuejia' ， DI Chunhong2

1 School of Public Health，Hangzhou Normal University，Hangzhou 311121，China （20 2 Departmentof ClinicalLaboratory，TheAflited HospitalofHangzhouNormalUniversity，Hangzhou31oo15，China

Corresponding author：TANXiaohuaTel：13989864087，E-mail：xiaohuatan@hznu.edu.cn

ABSTRACT：Asan indispensable trace element in the human body，copper plays an important role in various physiological and biochemical reactions.The dyshomeostasis of copper leads to the disorder of copper metabolism and the ocurrence of related diseases.Cuproptosis，a newly proposed regulatory cell death mode，is diffrent from the known apoptosis， pyroptosis，necroptosis，and ferrptosis.Recent studies have found that the dyshomeostasis of copper has been observed in avariety of cancers.Therefore，targeting copper for disease treatment maybecome a new strategy and anew idea.This article systematically summarizes the fundamental properties of copper，copper dyshomeostasis-related diseases （Menkes syndrome，Wilson’s disease，and cancer）and their treatment，and reviews the research progress in cuproptosis.

Key words：copper homeostasis；copper metabolism；cuproptosis；cancei

ActaAcadMedSin，2025，47（1）：102-109

銅作為多個信號傳導通路的關(guān)鍵調(diào)節(jié)因子以及多種酶的輔助因子，在線粒體呼吸、細胞增殖、抗氧化等各類生理過程中發(fā)揮著重要作用。（剩余16274字）