芒硝外敷聯(lián)合烏司他丁治療急性胰腺炎的效果及對實驗室指標(biāo)水平的影響

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Effect of External Application of Mangxiao Combined with Ulinastatin in the Treatment of Acute Pancreatitisand Its Influenceon Laboratory Indicators Levels/FUMingen，YI Suhong.//Medical Innovation of China，2025，22（18）：131-134

[Abstract]Objective：To explore the efect of external application of Mangxiao combined with Ulinastatin in thetreatmentofacute pancreatitis （AP）and its influenceonlaboratory indicators levels.Method：A total of 82 patients with APadmited to XinyuPeople's Hospital from June2O23 to June 2024 were selected and grouped bythe random number table method，with 41cases in the experimental groupand41 cases inthe control group.Thecontrol group was treated with Ulinastatin.Based on this，the experimental group was treated with external application of Mangxiao.The therapeutic efect，symptoms disappearance time，laboratory indicators，intestinal mucosal barrier functionand adverse reactions of the two groups were compared.Result： Compared with the control group，the total effectiverateof theexperimental groupwashigher，andthedisappearance timeofabdominal pain，nausea and vomiting and abdominal bloating were earlier （ P <0.05）.After treatment，compared with the control group，the levels of amylase （AMY）， white blood cellcount （WBC）， C reactive protein （CRP），endotoxin （ET），diamine oxidase （DAO） and D-lactic acid in the experimental group were lower，the diferences were statistically significant （ P <0.05）. No serious adverse reactions occurred in both group during the treatment period.Conclusion： External appication of Mangxiao combined with Ulinastatincan improve the laboratory indicators and intestinal mucosal barier functionof patients withAP，accelerate the relief ofsymptoms and improve the therapeutic effect，and itis safe.

[Key words]Acute pancreatitisExternal applicationof MangxiaoUlinastatinIntestinal mucosal barrier function

First-author's address： Department of Gastroenterology， Xinyu People's Hospital， Xinyu 338000， China

doi：10.3969/j.issn.1674-4985.2025.18.030

急性胰腺炎（AP）常見臨床表現(xiàn)有發(fā)熱、上腹疼痛、血尿淀粉酶升高等，相關(guān)研究認為，其主要因胰酶激活異常而致，通常伴有全身炎癥反應(yīng)和腸黏膜屏障功能受損表現(xiàn)，炎癥細胞在分泌過量氧自由基后，會進一步加劇AP炎性損傷，致其他臟器功能障礙[1-2]。（剩余5383字）