基于“脾腎互贊”理論探討內(nèi)質(zhì)網(wǎng)應(yīng)激在多囊卵巢綜合征中的作用

本文引用：，.基于“脾腎互贊"理論探討內(nèi)質(zhì)網(wǎng)應(yīng)激在多囊卵巢綜合征中的作用[J].湖南中醫(yī)藥大學(xué)學(xué)報，2025，45（5）：939-944.

[關(guān)鍵詞]脾腎互贊；多囊卵巢綜合征；內(nèi)質(zhì)網(wǎng)應(yīng)激；未折疊蛋白質(zhì)應(yīng)答；補(bǔ)腎健脾法 [中圖分類號]R271.1 [文獻(xiàn)標(biāo)志碼]A [文章編號]doi：10.3969/j.issn.1674-070X.2025.05.023

[Abstract]Polycysticovarysyndrome （PCOS） is a common reproductive endocrine system disease，and its pathogenesis is not completelyclear.Endoplasmicreticulumstress （ERS）isinvovedintheoccurrenceanddevelopmentofPCOSthroughtheunfolded proteinresponsesignalingpathwayhichisoselyelatedtoteathologicalproceessuchasgraulosacellapoptosiseive androgenchroniciflammation，andisulinsistance（I）ERSexhbitsaualoleinprotetingcelsandpromotingpotosis.It sharesmechanisticsimilaritieswiththetheoryof"splen-kidneymutualpromotion"inChinesemedicine，whereinspleenand kidneysynergisticallymaintainhebodyhealthunderphysiologicalconditions，yetleadtomutualdamageandcontributetodisease progressionunderpathologicalstates.Splenandkidneydeficiencycanlead to intracelularenvironmentdisorder，andthusinduce ERS，thecontinuousactivationof which furtheraggravatesthemetabolicandreproductivedysfunctionof COS.Basedonthe theoryof"spleen-kidneymutualpromotion，thispaperexplorestheroleofERSinthepathogenesisofPCOS，inordertofindthe relationshipbetweenthetwoandtoexplorethemechanismbywhichthekidneytonifyingandspleen-strengtheningtherapeutic method alleviates PCOS through regulation ofERS，soas to provide new ideasand methodsforthetreatmentof PCOS.

[Keywords]spleen-kidney mutual promotion； polycysticovary syndrome; endoplasmicreticulum stress；unfoldedprotein response; tonifying kidney and strengthening spleen method

多囊卵巢綜合征（polycystic ovary syndrome，PCOS）是一種常見的內(nèi)分泌代謝紊亂性疾病，其病理特征包括高雄激素血癥、排卵功能障礙及卵巢多囊樣改變等。（剩余14825字）