基于“肝主筋，腎主骨"理論辨證取穴溫針灸聯(lián)合膝痹方治療膝骨關(guān)節(jié)炎的臨床研究及模型化評價

打開文本圖片集

本文引用：劉順超，石昆，陳紹華.基于“肝主筋，腎主骨"理論辨證取穴溫針灸聯(lián)合膝痹方治療膝骨關(guān)節(jié)炎的臨床研究及模型化評價[J].湖南中醫(yī)藥大學(xué)學(xué)報，2025，45（5）：883-890.

1圖分類號]R245 [文獻標(biāo)志碼]B [文章編號]doi：10.3969/j.issn.1674-070X.2025.05.014

[Abstract]Objective To investigate the clinical eficacyof warmneedle moxibustionatselected acupoints from pattem identificationbasedonthetheoryof"livergoverssinewsandkidneygoversbones"combinedwiththeXibiFormulainthe treatmentofkneosteoarthris（KOA），aswellasitsimpactonserumiflammatoryfactorsandtoconstructaparmacodyamic model-basedevaluation.MethodsAtotalof97patientswithkneeosteoarthritis（KOA）admitedtoShanghaiChangningTianshan TraditionalChinese MedicineHospitalfrom September2O22to September2O24wereenroledinthisstudy.Thepatientswere randomlydividedintocontrol group（treatedwithwarmneedemoxibustionalone，n=49）andstudygroup（reatedwithacombination of warm needle moxibustion and the Xibi Formula， n=48 ），withbalanced baseline characteristics between the two groups.The Western OntarioandMcMaster UniversitiesOsteoarthritisIndex （WOMAC）scores，LequesneFunctionalAlgorithmIndexscores， TCM pattern scores， as well as serum levels of tumor necrosis factor- αα∝αααα （TNF- α ）and interleukins （IL），were compared between the twogroupsbeforeandaftertreatmentAnonlinearmixed-efectsmodelwasutilizedtoestablishatime-efectmodelforthe combinedtreatmentofwamnedlemoxibustionandXibiFormulainKOA.Themodelsgoodnessof-fitandparameterstability wereevaluated，anditspredictieperformancewasessedroughvisualizationandalysisasedonthefinalmodeltical time-efectcurvesforTCMpaternscoresundervariousbaselineconditions weresimulated.ResultsAftertreatment，thestudy groupexhibitedsignificantlyhighercureratesbasedonthe WMACscores，markedefectivenessrates，andoverallefectiveness rates based on the Lequesne scores compared to the control group （ Pe O.05）.After treatment，compared with the pre-treatment status， there was no statistically significant difference in fatigue and lassitude score in the control group （ P>0.05 ），while the scores of the study group decreased （ P 6 （ Pe ?1β ，and IL-6 compared to the control group （ P

[Keywords]kneeosteoarthritis;livergovernssinews;kidneygovernsbones;warmnedlemoxibustion;XibiFormula;in mmation response;pharmacodynamic model

膝骨關(guān)節(jié)炎（knee osteoarthritis，KOA）是一種常見的慢性退行性關(guān)節(jié)疾病，嚴(yán)重影響患者的生活質(zhì)量。（剩余10192字）