腸道菌群失調(diào)及外泌體在帕金森病機制中的研究進展

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【中圖分類號】 R742.5 【文獻標志碼】 A 【文章編號】 1672-7770（2025）02-0226-04

Abstract：Parkinson's disease（PD）isaneurodegenerative disease，and itspathogenesis has not been elucidated so far.Currntly，thegut-brainaxisandexosomesare the two major research hotspots inPD.Thedysbiosis intestinalfloraisinvolvedintheprogressionPDthroughthebrain-gutaxisbyaffctingthebody'sinflammation level，intestinal barrer permeability，and neuroinflammation.Exosomesplayan important roleinPDbyactingas communication messengers to participate in the activation neuroglial cells and the transmission a-syn. By summarizing theefects intestinal flora，exosomesand their synergisticeffectsinPD，wecanprovide some theoretical references for the occurrence and treatment PD.

Key words：parkinson disease；gut-brain axis；gut flora；exosomes

帕金森?。≒arkinson'sdisease，PD）是一種慢性神經(jīng)系統(tǒng)疾病，其主要特征是多巴胺能神經(jīng)元的喪失，在黑質(zhì)和紋狀體中出現(xiàn) -突觸核蛋白（ -synuclein， -syn）的異常積累。（剩余13488字）