膠質(zhì)母細胞瘤微環(huán)境中巨噬細胞極化影響因素的研究進展

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【中圖分類號】 R739.41 【文獻標志碼】 A 【文章編號】 1672-7770（2025）02-0219-04

Abstract：Glioblastoma（GBM） is the most aggessive form primary intracranial malignancy inadults，and its shortsurvivaldurationis intricatelylinked totheimmunosuppresiveefects mediatedbythetumor microenvironment. The phenotypic transition tumor-assciatedmacrophages（TAMs）ispivotal in establishing immunosuppressive milieuanddriving the progression the disease.This paper presentsa comprehensivereview pertinent literature andemerging research developments to examine the factors governing macrophage polarization within the GBM microenvironment and the underlying mechanisms involved.

Key words：tumor-associated macrophages；glioblastoma；tumor immune microenvironment；macrophage polarization； immunotherapy

膠質(zhì)母細胞瘤（glioblastoma，GBM）是成人中惡性程度最高的顱內(nèi)原發(fā)性惡性腫瘤，盡管現(xiàn)有的綜合治療手段不斷進步，患者中位生存期仍僅為15個月，5年生存率小于 。（剩余9368字）