魚(yú)類海洋分枝桿菌的研究進(jìn)展

打開(kāi)文本圖片集

中圖分類號(hào)：S941.42 文獻(xiàn)標(biāo)識(shí)碼：A 文章編碼：1005-8567（2025）03-0090-06

Abstract：Mycobacterium marinum，a typical pathogen causing zoonotic diseases in both humans and fish， exhibitsa complex infection mechanism with diversehostcharacteristics.Inrecentyears，theincidenceof mycobacteriosiscausedbythispathogeninglobalaquaculture hassignificantly increased.Aditionally，therisein human infectioncases highlights itspotentialpublic healthrisk.Thisreviewsystematicallysummarizes thegenetic diversityof M.marinum，its host adaptationandevolutionary mechanisms，and itspathogenic features in fish and humans.Special emphasis is placed on the molecular mechanisms mediated bythe ESX-1 secretion system，including immune evasion，lipid metabolismhijacking，andregulationofhostcell death.Integrating thecuting-edge application of the zebrafish model in tuberculosis research，this paper proposes an innovative approach to addresshost-specific infectionsthroughtheintegrationofmulti-omicsandsyntheticimmunologicaltechniques，providingatheoreticalbasis for the prevention and control of aquaculture pathogens and the early warning of zoonotic diseases.

Keywords：Mycobacteriummarinum;Fishinfection;Research progress

海洋分枝桿菌（Mycobacteriummarinum）是一種非結(jié)核分枝桿菌，能夠感染淡水魚(yú)與海魚(yú)，是淡水魚(yú)與海魚(yú)的主要致病菌1。（剩余8371字）