白血病患兒癌癥相關(guān)認(rèn)知障礙前哨因子及其評估工具研究進展

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【中圖分類號】R47

【文獻標(biāo)志碼】A【收稿日期】2024-10-04

Research advances in sentinel factors for cancer-related cognitive impairment and related assessment tools in children with leukemia

ZengYan'，Mo Lin2，Chen Zefang'，Liu Tao' （1.Chongqing Medical University School of Nursing/Departmentof Nursing，Children's Hospital of Chongqing Medical University;2.National Clinical Research Center for Child Health andDisorders/Ministryof Education Key Laboratory of Child Development and Disorders/Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders/Outpatient Department， Children's Hospital of Chongqing Medical University） 【Abstract】Cancer-relatedcognitiveimpaimentisacommonandseriouscomplicationinchildren withleukemia，whichaffects the qualityflongtermurvialandasdverseimpactoeirsholing，ife，ndocializatio.Toughaliteraturereviethistice summarizestelctofocaedieptinsoaietyepresgo ateexposure，decreasedlysophosphatidylholinelevelsandelevatedspingomyelinoncentratiosinerebrospialfuid，198 genotype，and increases in inflammatory factors（TNF- α ，IL-6，and IL-8）.The existing assessment tools for sentinel factors lack sensitivityandspeciicityndubsequentlargsampleuicentersdiessouldbeonductedtoalidateteccuracyofteboeidicatorsnpredictingcaner-relatedcognitiveimpairmentinchildrenwithlukemia，soastoachieveearlyinterventionandiprovethe quality of long-term survival.

【Keywords】leukemia;cognitive impairment;cancer;children

癌癥是全世界兒童死亡的主要原因，已成為國家重大公共衛(wèi)生問題[2-3]。（剩余16197字）