膀胱尿路上皮細胞焦亡在間質(zhì)性膀胱炎發(fā)病機制及其病理生理表現(xiàn)中的研究進展

打開文本圖片集

【中圖分類號】R69 【文獻標志碼】A

Research advances in the pathogenesis and pathophysiological manifestations of interstitial cystitis caused by urothelial cell pyroptosi：

Pang Lei'，Shuang Weibing2 （1.Department of Urology，Shanxi People's Hospital;2. Department of Urology， TheFirstHospital ofShanxiMedical University）

【Abstract】Pyroptosisisaproinflammatoryformofregulatedcelldeaththatcanleadtotheactivationofinactivecytokinesandthe cleavageofgasderinDincells.Themainpathologicaloucomeofiflammatorybladderdiseaseisthelossofbladdercompanceand cellpyrotosisplaysanimporantroleintisprocssSomestudieshvesownthatcellpyoptosisisegulatedbyariousnsms suchasDNAmethylationandmitochondrialDNAoxidativedamage，hichinterveneinthebiologicalbehaviorofbladderurothelial cellsin interstitialcystitisandinduceimpaimentofbladdercompliance.Therefore，tisarticleviewstheegulatorymechaissof cellpyoptoisitesialitdottalolfoosisintoddesasertplootl diagnostic biomarkers for interstitial cystitis and facilitate the preventionand treatmentof interstitial cystitis.

【Key wordslinterstitial cystitis;pyroptosis;DNA methylation;mitochondrial oxidative damage

間質(zhì)性膀胱炎/膀胱疼痛綜合征（interstitialcystitis/blad-derpainfulsyndrome，IC/BPS）是一種罕見卻具有潛在破壞性的盆腔疼痛障礙，以女性居多。（剩余14474字）