中醫(yī)辨證治療對(duì)高膽紅素血癥患兒臨床療效及血清總膽紅素水平的影響
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摘 要 目的：探討中醫(yī)辨證治療對(duì)新生兒高膽紅素血癥（NHB）患兒的臨床療效和血清總膽紅素水平（TSB）的影響。方法：將118例NHB患兒隨機(jī)分為對(duì)照組（n=59）和觀察組（n=59），對(duì)照組采用布拉酵母聯(lián)合光療治療，觀察組在此基礎(chǔ)上給以中醫(yī)辨證治療。結(jié)果：觀察組總有效率高于對(duì)照組（96.61% vs 89.83%）；治療后觀察組血清TSB、直接膽紅素（DBil）、總膽汁酸（TBA）、神經(jīng)元特異性烯醇化酶（NSE）和非結(jié)合膽紅素（UCB）水平低于對(duì)照組，新生兒神經(jīng)行為測(cè)定（NBNA）評(píng)分高于對(duì)照組，黃疸消失時(shí)間、皮膚顏色恢復(fù)正常時(shí)間、平均住院時(shí)間均少于對(duì)照組（均P
關(guān)鍵詞 中醫(yī)辨證 新生兒高膽紅素血癥 血清總膽紅素 NBNA評(píng)分
中圖分類號(hào)：R272.1 文獻(xiàn)標(biāo)志碼：A 文章編號(hào)：1006-1533（2022）07-0035-05
引用本文 王品， 徐會(huì)民. 中醫(yī)辨證治療對(duì)高膽紅素血癥患兒臨床療效及血清總膽紅素水平的影響[J]. 上海醫(yī)藥， 2022， 43（7）： 35-39.
Effect of TCM dialectical therapy on clinical efficacy and total serum bilirubin level in neonatal hyperbilirubinemia
WANG Pin， XU Huimin
（Department of Pediatrics， the Central Hospital of Nanyang City， Nanyang 473000， China）
ABSTRACT Objective： To investigate the effect of dialectical treatment of traditional Chinese medicine （TCM） on clinical effect and total serum bilirubin （TSB） level in neonates with hyperbilirubinemia （NHB）. Methods： One hundred and eighteen children with NHB were randomly divided into a control group （n=59） and an observation group （n=59）. The control group was treated with light therapy combined with Saccharomyces boulardii while the observation group with traditional Chinese medicine besides. Results： The overall response rate in the observation group was higher than that in the control group（96.61% vs 89.83%）. After treatment， the levels of serum TSB， DBIL， TBA， NSE and UCB were lower， the scores of NBNA were higher and the time for jaundice disappearance and skin color recovery and the average hospital stay were shorter in the observation group than the control group （all P
KEy wORDS TCM dialectics； neonatal hyperbilirubinemia； total serum bilirubin； neonatal behavioral neurological assessment
新生兒高膽紅素血癥（neonatal hyperbilirubinemia， NHB）是一種以皮膚顏色變黃、血清總膽紅素（total serum bilirubin， TSB）升高為主要表現(xiàn)的疾病[1]，又稱新生兒黃疸，在我國(guó)的發(fā)病率高達(dá)48.20%[2]。（剩余5939字）