左乙拉西坦聯(lián)合奧卡西平在小兒癲癇治療中的效果及不良反應(yīng)分析

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【摘要】目的：探究癲癇患兒在治療過程中應(yīng)用左乙拉西坦與奧卡西平聯(lián)合治療的效果。方法：平均將76例癲癇患兒分為參照組與研究組，每組38例，比較兩組治療效果、異常放電控制情況、血清指標(biāo)、智力水平以及不良反應(yīng)發(fā)生情況。結(jié)果：治療后，研究組治療總有效率為97.37%，PIQ評分、VIQ評分及FIQ評分分別為（108.36±4.92）分、（102.65±4.64）分及（116.53±4.25）分，GFAP、S-100β、IgA及IgG水平分別為（2.53±0.42）ng/L、（0.40±0.09）μg/L、（0.24±0.09）g/L及（6.54±1.29）g/L，異常放電控制率及不良反應(yīng)發(fā)生率分別為97.37%及5.26%，上述指標(biāo)均優(yōu)于參照組（P

【關(guān)鍵詞】小兒癲癇；左乙拉西坦；奧卡西平；療效；不良反應(yīng)

Analysis of the effect and adverse reaction of levetiracetam combined with oxcarbazepine in the treatment of epilepsy in children

GUO Li， TANG Yan

Neijiang Health Vocational College， Neijiang， Sichuan 641100， China

【Abstract】Objective：To explore the effect of the combination therapy of leve tiracetam and oxcar bazepine in the treatment of children with epilepsy.Methods：An average of 76 epileptic children were divided into the reference group and the study group，with 38 cases in each group.The therapeutic effect，abnormal discharge control，serum indicators，intelligence level and adverse reactions of the two groups were compared.Results：After treatment，the total effective rate of treatment in the study group was 97.37%，PIQ score，VIQ scoreand FIQ score were （108.36±4.92）points，（102.65±4.64）points and（116.53±4.25）points，GFAP，S-100β，the IgA and IgG levels were（2.53±0.42） ng/L，（0.40±0.09）μg/L，（0.24±0.09） g/Land（6.54±1.29） g/L，the control rate of abnormal discharge and the incidence of adverse reactions were 97.37% and 5.26% respectively，which were better than those in the reference group（P

【Key？Words】Epilepsy in children； Levetiracetam； Oxcarbazepine； Efficacy； Adverse reactions

癲癇多發(fā)生于兒童時期，是一種具有復(fù)雜病因的腦功能障礙綜合征，該病雖是慢性疾病，但會因反復(fù)發(fā)作而使患兒高熱驚厥、全身強制性陣攣等癥狀愈發(fā)嚴(yán)重，嚴(yán)重影響了患兒的機體健康水平[1]。（剩余3710字）