競(jìng)爭(zhēng)性內(nèi)源性RNA在牙周炎中的作用及機(jī)制的研究進(jìn)展

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[中圖分類號(hào)]R781.4 [文獻(xiàn)標(biāo)志碼] A[doi] 10.7518/gjkq.2025042
Research progress on the role and mechanism of competitive endogenous RNAinperiodontitis
FanXingli,PanLe,ZhaoJiayuan,XiangQiumeng,ChenQilin
Dept.ofStomatologyTaiheHospitalofHubeiUniversityofedicine,InstituteofOralDiseases,chooloftotology
HubeiUniversityofMedicine,Shiyan4420oo,China
Supported by:HubeiProvincial Health CommissionResearchProject(WJ2021M049);GuidingProjectofScientificRe
searchPlanofHubeiProvincialDepartmentofEducationin2022(B2022499)
Correspondence:ChenQilin,Email:drchenqilin@126.com
[Abstract]Research has found that competitive endogenous RNA (ceRNA)regulates the progression of periodontitis by modulating the transcriptional responseof inflammation-related mediators.ceRNA,including long noncoding RNA, circularRNA,andmessengerRNA,canbind tomicroRNA toformaceRNAnetwork,regulate theexpressionof downstreamtarget genes,and influencetheoccurrenceanddevelopmentof periodontitis.Thisarticlesummarizes theroleand mechanismofceRNA inregulatingtheoccurrenceand development ofperiodontitis that have been verifiedby experimentalevidence.This article alsoreviews theresearch progressin inhibiting and promoting theoccurrenceand development of periodontitis,and provides new ideas for future research on periodontitis.
[Key Words] competitive endogenous RNA;periodontitis;microRNA; long non-coding RNAs;circular RNA
牙周炎是牙周組織廣泛存在的慢性感染性病變。(剩余13170字)