牙齦卟啉單胞菌影響血管平滑肌細胞調(diào)節(jié)性細胞死亡及表型轉(zhuǎn)換的研究進展

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[中圖分類號]R780.2[文獻標志碼]A[doi] 10.7518/gjkq.2025055

Research progressinto the effects of Porphyromonas gingivalis on regulatory celldeath and phenotypic switching of vascular smooth muscle cells

BieMengyao，ZhouJieyu，WuYafei，Zhaoei

StateKeyLaboratoryofOralDiseases&NationalCenterforStomatology&NationalClinicalResearchCenterforOral Diseases&ptridontologyWestaHosptalototologyianUersitygduin Supportedby：NationalNaturalScienceFoundationofChina （81970944）；NationalNaturalScienceFoundationofChina YouthFund （823o089）；Researchndveloprogram，WesthinaHospitaloftomatologyichanUnivesityD02-202407）

Correspondence：ZhaoLei，Email：jollyzldoc@163.com

[Abstract]Periodontitis isachronic inflammatorydiseasecausedbybacterial infection.Epidemiologicalstudiesandin vivo/invitroresearchhaveconsistentlydemonstratedastrongasociationbetweenperiodontitisandanincreasedriskof cardiovascular diseases.Vascular smooth muscle cells （VSMCs）participate in the pathogenesisof atherosclerosis，aortic aneurysms，and vascularcalcification viaregulatedcelldeath mechanisms （inluding autophagyapoptosis，and pyopto sis）andphenotypic switching.Porphyromonas gingivalis，acritical periodontal pathogen，alters VSMCbiological behavior，notonly invading VSMCs to influence their regulated celldeath processbutalso promoting phenotypic switching characterized by proliferation，migration，and calcification.These mechanisms playpivotalroles incardiovasculardisease

development. This review aims to synthesize recent research advances and elucidate the connections between periodontitisand VSMC-regulated cell death/phenotypic switching.Novel insightsinto improved preventionand treatment strategies for periodontitisand cardiovascular diseases are provided.

[Key words] Porphyromonas gingivalis； vasculai smooth muscle cell； cardiovascular diseases； phenotypic switching； periodontitis

牙周炎是由菌斑微生物引起的慢性感染性疾病，表現(xiàn)為牙周支持組織破壞，例如牙周袋形成、附著水平喪失、牙槽骨吸收、牙齒脫落等，能夠造成口腔局部及全身的慢性炎癥。（剩余21508字）