自組裝多肽及其抗菌作用研究進展

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中圖分類號：R75 文獻標志碼：A 文章編號：1673-3851（2025）07-0580-08

引用格式：，等．自組裝多肽及其抗菌作用研究進展[J.浙江理工大學學報（自然科學），2025，53（4）：580-587.

Abstract： Bacterial infections constitute a common public health challenge， as the escalating antimicrobial resistance significantly compromises the therapeutic eficacy of conventional antibiotics. Distinct from conventional antibiotics and chemical agents，self-assembling peptides can achieve broadspectrum antibacterial efects through bacterial membrane disruption and synergistic enhancement of other antimicrobial components，demonstrating advantages including rapid bactericidal action and low resistance induction potential. Furthermore，these peptides demonstrate exceptional molecular design flexibility， targeting specificity，and environmental responsiveness， positioning them as promising candidates for Overcoming current antimicrobial resistance challenges. Recent research advancements have focused on molecular structure optimization， development of stimuli-responsive materials，and engineering of in vivo delivery systems， achieving important progress in wound dressng applications and targeted drug delivery. This review systematically examines the antimicrobial mechanisms，molecular design principles，and clinical translation progress of self-assembling peptides，while discussing future research directions and challenges.The analysis provides both theoretical frameworks and practical reference for developing nextgeneration antimicrobial self-assembling peptide-based therapeutics.

Key words：biomaterials；self-assembling peptides；bacterial infections；antimicrobial mechanisms drug delivery; molecular design

0 引言

細菌感染對公共衛(wèi)生安全構成重大威脅，其引發(fā)的疾病可累及全身各器官系統(tǒng)，嚴重危害人類健康[]。（剩余19282字）