八水碳酸鑭脫水熱力學特性及四水碳酸鑭超聲制備新技術

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中圖分類號：R917 文獻標志碼：A 文章編號：1673-3851（2025）07-0461-08

引用格式：，等．八水碳酸鑭脫水熱力學特性及四水碳酸鑭超聲制備新技術[J．浙江理工大學學報（自然科學），2025，53（4）：461-468.

Abstract： To develop a new technology for the preparation of lanthanum carbonate tetrahydrate （La2（CO3）3?4H2O） ，thermal gravimetric analyzer and differential scanning calorimeter were employed to investigate the thermodynamic dehydration process of lanthanum carbonate octahydrate （La2（CO3）3?8H2O） Furthermore，the activation energy for each dehydration stage was calculated using the Ozawa equation. Based on this， ultrasonic technology was introduced to facilitate the dehydration of La2（CO3）3?8H2O to prepare La2 （CO3）3?4H2O ， and the phase， elemental composition， morphological structure， and phosphate binding capacity of La2（CO3）3?4H2O were analyzed. The results indicated that La2（CO3）3?8H2O sequentially lost 2， 2，and 4 crystal waters at 80°C ， 105°C ，and 350°C ，respectively，and after losing 4 crystal waters， La2（CO3）3?8H2O could transform into the more thermodynamically stable La2（CO3）3?4H2O The La2（CO3）3?4H2O produced by ultrasonic technology had high phase purity，contained no impurity elements，and exhibited a morphology of uniformly dispersed flakes. In addition，the phosphate binding rate of La2（CO3）3?4H2O reached 98.27% within 27O minutes， demonstrating excellent phosphate binding efficiency.

The La2（CO3）3?4H2O prepared using ultrasonic technology in this study，which exhibits excellent dispersibility and high phase purity， has significant potential in the treatment of hyperphosphatemia.

Key words： lanthanum carbonate octahydrate （La2（CO3）3?8H2O） ; dehydration; activation energy; ultrasonic technology;lanthanum carbonate tetrahydrate （La2（CO3）3?4H2O）

0 引言

碳酸鑭在胃腸道環(huán)境釋放的三價鑭離子能有效結合體內(nèi)的磷酸鹽，形成難溶性磷酸鑭復合物而隨糞便排出，因而可作為降磷藥物用于治療高磷血癥[1]。（剩余7690字）