+</sup> T淋巴細(xì)胞亞群和 CD8<sup>+</sup> T淋巴細(xì)胞亞群，這些細(xì)胞亞群通過(guò)分泌細(xì)胞因子，在COPD中介導(dǎo)炎癥反應(yīng)和參與免疫調(diào)節(jié)過(guò)程。當(dāng)T細(xì)胞亞群比例失衡時(shí)，可導(dǎo)致免疫失衡，加重肺組織損傷。自前針對(duì)COPD的T淋巴細(xì)胞的免疫治療，主要以抗炎和免疫調(diào)節(jié)為主，包括單克隆抗體、疫苗及化學(xué)制劑等干預(yù)手段。本文主要綜述T淋巴細(xì)胞在COPD發(fā)生發(fā)展及免疫治療中的作用，旨在為臨床治療提供新的理論依據(jù)。-龍?jiān)雌诳W(wǎng)" />

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T淋巴細(xì)胞在慢性阻塞性肺疾病發(fā)生發(fā)展及免疫治療中的作用

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關(guān)鍵詞：肺疾病，慢性阻塞性；T淋巴細(xì)胞；免疫治療

中圖分類號(hào)：R563.9文獻(xiàn)標(biāo)志碼：A文章編號(hào)：1001-5779（2025）05-0485-07

DOI：10.3969/j.issn.1001-5779.2025.05.013

Abstract：Tlymphocytes playa keyrole in the occurrence and developmentof chronic obstructive pulmonary disease （COPD）. They are classified into CD 4+ Tlymphocyte subsets and CD8+T lymphocyte subsets according to the expression of clusterofdiferentiation（CD），which mediate inflammatoryresponses and participate in immuneregulation processes in COPDthroughthesecretionofcytokines.WhentheproportionofTcellsubpopulationsisimbalanced，itcanlead to immuneimbalance andaggravate lung tissue damage.Currently，Tlymphocyte-related immunotherapyfor COPD mainly focuseson anti-inflammation and immune regulation，including intervention measuressuch as monoclonal antibodies， vaccines，andchemicalagents.Thisarticlemainlyreviews theroleofTlymphocytes intheoccurrenceanddevelopment of COPD and in immunotherapy，aiming to provide a new theoretical basis for clinical treatment.

Keywords：Pulmonary disease，chronic obstructive；Tlymphocytes；Immunotherapy

慢性阻塞性肺疾?。–hronicobstructivepulmo-narydisease，COPD）是以持續(xù)性氣流受限為主要特征的慢性呼吸道疾病，常表現(xiàn)為持續(xù)性的呼吸道癥狀[]。（剩余18538字）

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