壞死性凋亡在病毒感染性疾病中的研究進展

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Abstract:Necrotic apoptosis is a regulated mannerof celldeath,usuall triggered by the binding of death re ceptors and tumor necrosis factors or viral infection. Unlike cell apoptosis,necrotic apoptosis is characterized by cell sweling,membrane rupture,and the release of cytoplasmic contents,which may trigger an inflammatory response and surrounding tissue damage. The discovery process and molecular mechanism of necrotic apoptosis are reviewed,and the TNF- α signaling pathway and the formation of receptor interacting protein kinase 1(RIPK1)/receptor interacting protein kinase 3(RIPK3) complex are focused on discussing. At the same time,the central role of active oxygen in RIPK1-mediated necrotic apoptosis is emphasized and the key role of necrotic apoptosis in host antiviral defense is explained.This review providesa reference of the biological function of necrotic apoptosis and also a theoretical basis for the development of new therapeutic strategies.
Keywords: necrotic apoptosis;virus;programmed cell death;active oxygen
壞死性調(diào)亡的發(fā)現(xiàn)
壞死性凋亡是一種受調(diào)控的細胞死亡過程,其受細胞外及細胞內(nèi)的信號調(diào)控,包括死亡受體-配體結(jié)合、病原體感染等,是不同于細胞凋亡、焦亡與自噬的細胞死亡方式。(剩余16378字)