雙能CT技術在高原地區(qū)高尿酸血癥患者四肢關節(jié)尿酸鹽沉積檢查中的應用

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Applicationof dual-energyCTinurate deposition in limbsof patientswith hyperuricemiaat high altitude BaiRuiting，Cianwangjiu，Zhang Png，BianBaciren，LeiYanmin.Departmentof RadiologyXizang Autonomous RegionPeople'sHospital，Lasa850oO0，Chin

【Abstract】 ObjectiveTo explore the application value of dual-energy CT in the examination of urate depositionin limbs of patientswith hyperuricemiain theplateau area.MethodsFrom January 2O23 to December 2023，31 patients with hyperuricemia diagnosed by clinical uric acid detection in Xizang Autonomous Region People'sHospital and28patients innon-hyperuricemia group wereretrospectivelyanalyzed.All patientsreceived dual-energyCTexaminationofoneormore joints in limbsatleastonce，andthedetectionrateofuricaciddeposition inlimbsof patientswith hyperuricemiain theplateau area wasanalyzed.ResultsSatisfactorydual-energy CT images were obtained in both groups.In31 patients with hyperuricemia，the average serum uricacid content was （487±42）μmol/L，whilein28 patients without hyperuricemia，the average serum uricacid content was （325±59）μmol/ L.There was a statistical diference between the two groups t=12.27 ，P<0.001）. There were 82 joints in the hyperuricemia group and 59 joints in the non-hyperuricemia group.The detection rateof joint urate deposition in he hyperuricemic group was 100% ，and that in the non-hyperuricemic group was 37.2% . The difference between the two groups was statistically significant （ P <0.05）.Patients with positive urate crystals showed patches or nodules of green urate crystalsaroundfeet，ankles，knees，andwrists，and somepatientscouldseelocalizedboneerosion.Dual-energy CTfindingsof patients with negative uratecrystals were normal，andno green urate crystals were found.Conclusion

Dual-energy CTcan clearlyand non-invasively display theurate deposition in the joints of limbs of patients with hyperuricemiaathighaltitudes，which providesanimportantscientificbasis for theclinical diagnosisandtreatment of gout at high altitudes.

高原地區(qū)，痛風發(fā)病率遠高于內地[]，可能原因是高原地區(qū)飲食結構與平原地區(qū)不同，高原地區(qū)人群飲食結構相對單一，蔬菜水果攝入較少，而以肉類及酥油等高蛋白及高脂飲食為主，另外高原地區(qū)長期缺氧導致高原性紅細胞增多而導致高尿酸血癥[2]。（剩余3642字）