3</sub>[25(OH)D<sub>3</sub>] 與2型糖尿病(T2DM)患者腎功能指標(biāo)的相關(guān)性。方法選取我院2023年11月至2024年11月80例2型糖尿病患者作為研究對象,以尿白蛋白定量 (24h)(24h 1UAE)作為分組標(biāo)準(zhǔn),分為正常組(31例)、微量組(27例)以及大量組(22例)。分別對3組患者的25(OH)D3以及腎功能指標(biāo)進行檢測,分析兩者之間的相關(guān)性。結(jié)果3組性別占比、年齡、糖化血紅蛋白 (HbA<sub>1</sub>c) 、高密度脂蛋白膽固醇(HDL-C)指標(biāo)對比差異無統(tǒng)計學(xué)意義 (P>0.05) 病程、體質(zhì)指數(shù)、空腹血糖等其他指標(biāo)差異均有統(tǒng)計學(xué)意義 (P<0.05) 。微量組僅有 25(OH)D3 低于正常組 (P<0.05) ，其余指標(biāo)與正常組對比差異無統(tǒng)計學(xué)意義 P> 0.05);大量組僅有性別、年齡、HbA1c以及HDL-C與正常組、微量組差異無統(tǒng)計學(xué)意義 (P>0.05) ，其余指標(biāo)均明顯高于正常組、微量組 (P<0.05) 。Pearson相關(guān)性分析結(jié)果顯示 ?<sub>25(OH)D3</sub> 與尿素氮、血肌酐、血尿酸以及 {β<sub>2</sub>} 微球蛋白指標(biāo)均呈現(xiàn)出負相關(guān)關(guān)系 (r=-0.221?-0.493?-0.198?-0.405,P<0.05) 。結(jié)論25(OH)D3缺乏的T2DM患者,腎功能指標(biāo)存在明顯異常的腎臟病變的風(fēng)險性更高,值得臨床中加以重視。-龍源期刊網(wǎng)" />

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25羥基維生素 D3與2型糖尿病患者腎功能指標(biāo)的相關(guān)性分析

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Analysisofthecorrelationbetween25hydroxyvitamin D3 andrenal function indexesin type2diabetes mellitus patients

Li Dandan， JinJiapei，WangYuanyuan Clinical LaboratoryLuoyangFirstPeople'sHospital，Luoyang47looo，China

【Abstract】 Objective To analyze the correlation between 25 hydroxyvitamin D3 [25（OH）D3] and renal function indexes inpatientswith type2 diabetesmelitus （T2DM）.MethodsA total of 8O patients with type 2 diabetes melitus in our hospital from November 2023 to November 2024 were selected as the study subjects，and were divided into the normal group （n=31）， the trace group （ n=27 ），and thelarge amount group （ n =22）using the quantitative urinary albumin （24h-UAE） as the grouping criterion. The 25（OH）D3 and renal function indexes of the patients in the3 groups were tested separately，and thecorrelation between them was analyzed.ResultsThere were no significant differences in the comparison of gender percentage， age， HbA1c and HDL-C indexes among the 3 groups （ P >0.05），while the comparison of the rest of the indexes showed significant differences （ P <0.05）. In the trace group，only 25（OH）D3 was lower than those of the normal group （ P <0.05），and the rest of the indexes were not significantly different in comparison with the normal group （ P>0.05 ）; in the large amount group，only gender， age， HbA1c，and HDL-C were not significantly diferent from that of the normal group and the trace group （ P >0.05）， and the rest of the indexes were significantly higher than those of the normal group and the trace group （ P <0.05）.Pearson Results of correlation analysis showed that25（OH）D3 showed negative correlation withBUN，SCr，UA，and β2-MG indexes（ r= -0.221，-0.493，-0.198，-0.405，P<0.05）.ConclusionPatientswith type2 diabetes melltus with 25 （OH）D3 deficiency have significantabnormalities inrenal function indexes andahigher risk of nephropathy，which deserves attention in the clinic.

【Key words】 25 hydroxyvitamin D3；Diabetes mellitus，type2；Renal function; CorrelationDOI：10.19522/j.cnki.1671-5098.2025.05.012

2型糖尿?。═2DM）是臨床中最常見的慢性疾病類型之一，當(dāng)患者機體長期處于高血糖狀態(tài)下，可能增加各類并發(fā)癥的發(fā)生率，例如大血管并發(fā)癥、微血管并發(fā)癥等。（剩余6069字）

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