多模態(tài)超聲對乳腺良惡性結(jié)節(jié)的鑒別診斷及在不同Ki-67表達的惡性結(jié)節(jié)中的特征

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Differential diagnosis of benignand malignant breast nodules bymultimodal ultrasonography and the characteristicsofKi-67expressionindifferentmalignantnodules

Xia Qianqian DepartmentofUtrasonography，KaifengHospitalofrditionalinesedicine，Kaifeng475ooina

【Abstract】 Objective To investigate the diffrential diagnosis of benignand malignant breast nodules by multimodal ultrasoundandthediferenceof proliferatingcellnuclearantigen 67（Ki-67） expression inmalignant nodules.MethodsEighty-six patients with high-risk malignant breast nodulesadmited toourhospital from July 2021 to July 2O24 were selected.All patientsunderwent surgical resection，received multimodal ultrasonography before surgery，andunderwent pathological diagnosisaftersurgery，the diagnosisof 86 patientswasanalyzed， includingthedifferentialdiagnosisefectofmultimodalultrasoundinbenignandmalignantbreastnodules，and the characteristicsof multimodal ultrasound in patients withdiffrentexpressonlevelsofKi-67inmalignant nodules. ResultsInthe diferential diagnosis of benign and malignant breast nodules，the accuracyof multimodal ultrasound was 96.51% ，thespecificitywas 96.08% ，and the sensitivitywas 97.14% ，whichwerehigherthanthose of conventional ultrasound，ultrasound elastography and contrast-enhanced ultrasound alone （ P <0.05）. In the routine ultrasound examination of malignant nodules，the tumor size and marginalburrsign of Ki-67 high expression group were higher than those of Ki-67 low expression group（ P <0.05）.The hard ring sign of Ki-67 high expression group was higher than that of Ki-67 low expression group （ P <0.05）.Contrast-enhanced ultrasound showed that the perfusion defect rate of Ki-67 high expression group was higher than that of Ki-67 low expression group （ P <0.05）. Conclusion

Inthediffrentialdiagnosisofbenignandmalignantbreast nodules，multimodalultrasoundhasgoodapplication value，andthefindingsofmultimodalultrasoundarerelated totheexpressionlevelofKi-67inmalignant nodules， which can provide more references for the prognosis evaluation of patients.

【Key words】 Multimodal Imaging;Ultrasonography，breast;Ki-67

DOI：10.19522/j.cnki.1671-5098.2025.05.007

在女性惡性腫瘤中，乳腺癌發(fā)病率居于首位，而相關(guān)報道顯示，早期乳腺癌通過實施規(guī)范化治療后，可達到 98% 的五年生存率，而晚期乳腺癌患者僅可達到 23% 的五年生存率[12]。（剩余7808字）