胞磷膽堿鈉聯(lián)合經(jīng)顱刺激治療腦卒中后認知功能障礙的效果及對認知能力和炎癥因子的影響
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I RehabilitationDepartmentofJingbian CountyPeople'sHospital，Yulin7185oo，China; 2 GastroenterologyDepartment
ofJingbianCounty People'sHospital inYulinCity，Yulin7185oo，China
Corrsepondingauthor：WangHaiyang，Email：15529811701@163.com
【Abstract】Objective To observe and explorethe clinical effects of combined use of repetitive transcranial magnetic stimulation （rTMS）and citicolinesodium therapyoncognitive impairment patients after stroke，as wellas their effects oncognitive abilityand inflammatory factors.MethodsA totalof12Opatients with cognitive impairment after stroke were admitted from May2O22 to November 2O23.They were randomlydivided intoa control group （ n =60，treated with rTMS）and an observation group（ n =60，treated with rTMSand added with citicoline sodium）usingarandomnumber tablemethod.Comparecognitivecognitiveability，abilitytolive，cerebral hemodynamics，and inflammatory factorsbeforeand after treatment were compared.ResultsAfter 4 weeks of treatment，theMontreal Cognitive Assessment Scale （MoCA） score，Activitiesof Daily Living （ADL）score，mean cerebral artery blood flow velocity（Vm），peak cerebral artery flow velocity （Vs），and transforming growth factor- （TGF - β1 ） in the observation group were significantly higher than those in the control group，while monocyte chemoatractant protein-1（MCP-1）and interleukin-6 （IL-6） were significantly lower than those in the control group （all P <0.05）.ConclusionrTMS treatment combined with citicoline sodium has a definite therapeutic effect on cognitive impairment patients after stroke，whichcan significantlyreduce neurological deficits，improvecognitive andliving abilities，improvecerebral hemodynamics，and inhibit upregulationof inflammatory factors.
【Key words】 Stroke;Cognitive impairment；Repetitive transcranial magnetic stimulation； Cytidine sodium;Inflammatory factorsDOI：10.19522/j.cnki.1671-5098.2025.01.018
腦卒中發(fā)病率、致殘率及死亡率高，在中老年人群中多見，尤其是缺血性卒中，腦卒中遺留認知功能障礙的風險高達 30% 及以上1，常導致患者語言功能受損、無法集中注意力、記憶功能減退、執(zhí)行力下降、思維反應(yīng)遲緩，嚴重影響患者認知能力及日常生活質(zhì)量[2]。（剩余5485字）