2</sup> 血管總橫截面積/肺野總面積(CSA5-10)低于預(yù)后良好組[CSA： ?5.6±1.5?mm<sup>2</sup> 和 7.1± 1.6)mm<sup>2</sup>,t=3.830,P<0.001;%CSA5-10;(41.8±7.3)% 和 (761.3±11.2)% t=8.663,P<0.001] ，預(yù)后不良組 <5mm<sup>2</sup> 血管總橫截面積/肺野總面積（ %CSA<5 高于預(yù)后良好組[CSA： 59.5±5.8)% 和 (47.2±9.9)% ， t=-6.451 P< 0.001]。多元回歸分析法分析發(fā)現(xiàn)CSA[OR值 (95%CI)=0.457(0.307,0.680) ， P<0.001 一 % CSA5-10[OR值(95%C1)=0.498(0.253,0.980)， P<0.001. 和 1%0%0.588<5[OR(95%CI)=2.375(1.377,4.095),P<0.001] 等CT肺小血管參數(shù)與肺動(dòng)脈高壓患者的預(yù)后具有相關(guān)性。ROC曲線分析發(fā)現(xiàn)， %CSA5–10 預(yù)測(cè)肺動(dòng)脈高壓患者預(yù)后的臨床價(jià)值良好 [AUC(95%CI)=0.924(0.833,0.974),P<0.001] 。結(jié)論CT肺小血管參數(shù)與肺動(dòng)脈高壓患者預(yù)后具有一定的相關(guān)性，且可為臨床預(yù)測(cè)患者預(yù)后提供有效客觀依據(jù)。-龍?jiān)雌诳W(wǎng)" />

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肺動(dòng)脈高壓患者隨訪及CT定量監(jiān)測(cè)的評(píng)估價(jià)值研究

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Astudy of the relationship between CTparameters of pulmonarysmall vessel parametersand the

prognosisof patientswith pulmonary hypertension

CaiLeilei

DepartmentofRadiology，BaofengBranch，theSecondPeople'sHospitalofPingdingshanCity，Pingdingshan 467400， China

【Abstract】Objective To investigate the relationship between CT parameters of pulmonary small vessels and prognosis of patients with pulmonary hypertension.MethodsCT scan data of 68 patients with pulmonary hypertension treated inourhospitalfrom January 2020 to December2O22 were retrospectivelyanalyzed.Allpatients were followed up for one year，and were divided into good prognosis group （ n =39 cases） and poor prognosis group （ n= 29）according to follow-up outcomes. CT parameters of pulmonary small vessels were compared two weeks after admission.Multivariate regression was used to analyze the correlation between CT pulmonary small vessel parameters and the prognosis of patients with pulmonary hypertension，and receiver operating characteristic curve （ROC curve） wasused to analyze the clinical value of CT pulmonary small vessel parameters in predicting the prognosis of patients with pulmonary hypertension. ResultsThe CSA and % CSA5-10 in the poor prognosis group were lower than those in the good prognosis group [CSA：（5.6±1.5）mm2 vs.（7.1±1.6）mm2 ; τ =3.830， P<0.001 % CSA5- 10： （41.8±7.3）% vs.（61.3±11.2） % t=8.663 P<0.001 ]， the % CSA<5 in the poor prognosis group was higher than that in the good prognosis group [CSA：（59.5±5.8）% vs. （47.2±9.9）%; t= -6.451， P <0.001]. Multiple regression analysis found that CSA[OR（95%CI）=0.457（0.307 ，0.680），P<0.001]， % CSA5-10[0R（95%CI） ≡= 0.498（0.253，0.980）， P< 0.001] and 095）， P <0.001] were correlated with the prognosis of patients with pulmonary hypertension. ROC curve analysis showed that %CSAS-10 had good clinical value in predicting the prognosis of patients with pulmonary hypertension [AUC（95%C1）=0.924（0.833，0.974），P<0.001]. ConclusionCT parameters of pulmonary small vessels have a certaincorelation with the prognosis of patients with pulmonary hypertension，and can provide an efective objective basis for clinical prediction of patient prognosis.

【Key words】Pulmonary hypertension； CT; Small pulmonary vessels；Prognosis；Correlation；Predictivevalue

DOI：10.19522/j.cnki.1671-5098.2025.01.009

肺動(dòng)脈高壓是一種由多種異源性疾病和不同發(fā)病機(jī)制引起的臨床綜合征，主要病理特征是肺血管結(jié)構(gòu)或功能改變，可導(dǎo)致肺動(dòng)脈壓力升高，并且隨著病程的發(fā)展，肺血管阻力會(huì)逐漸增大，誘發(fā)右心衰竭甚，加大患者死亡風(fēng)險(xiǎn)[1-2]。（剩余7783字）

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