Wnt/β-catenin與胰腺癌早期轉(zhuǎn)移相關(guān)性的研究進(jìn)展

【摘 要】胰腺癌是起源于胰腺的惡性腫瘤，生存率極低，復(fù)發(fā)率極高，嚴(yán)重影響患者生命質(zhì)量。胰腺癌較早出現(xiàn)轉(zhuǎn)移，早期診斷較困難，化療過程易出現(xiàn)化學(xué)耐藥。Wnt信號(hào)通路與胰腺癌遷移、侵襲、轉(zhuǎn)移有關(guān)。本文綜述了Wnt信號(hào)通路及其與癌癥及胰腺癌侵襲和轉(zhuǎn)移的關(guān)系，以期為胰腺癌的治療和控制尋找新的突破口。

【關(guān)鍵詞】Wnt/β-catenin信號(hào)通路；胰腺癌；遠(yuǎn)處轉(zhuǎn)移

中圖分類號(hào)：R735.9 文獻(xiàn)標(biāo)識(shí)碼：A 文章編號(hào)：1004-4949（2022）19-0101-03

Research Progress on the Correlation Between Wnt/β-catenin and Early Metastasis of Pancreatic Cancer

GUO Bin-bin1， NAN Jin-niang1， XU Wen-peng2

（1.Department of Clinical Medicine， Nanchang Medical College/Jiangxi Health Vocational College， Nanchang 330052， Jiangxi， China； 2. Department of Encephalopathy， Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine， Nanchang 330006， Jiangxi， China）

【Abstract】Pancreatic cancer is a malignant tumor originated from the pancreas， with extremely low survival rate and high recurrence rate， which seriously affects the quality of life of patients. Pancreatic cancer has early metastasis， early diagnosis is difficult， and chemotherapy is prone to chemical resistance. Wnt signaling pathway is related to migration， invasion and metastasis of pancreatic cancer. This article reviews the Wnt signaling pathway and its relationship with cancer and pancreatic cancer invasion and metastasis， in order to find a new breakthrough for the treatment and control of pancreatic cancer.

【Key words】Wnt/β-catenin signaling pathway； Pancreatic cancer； Distant metastasis

胰腺癌（pancreatic cancer）是預(yù)后最差的惡性腫瘤之一，發(fā)病率逐年上升，5年生存率低于8%，復(fù)發(fā)率高達(dá)75%～90%[1]。（剩余5362字）