液相色譜柱使用時間對水產(chǎn)品中磺胺類檢測結(jié)果的影響

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中圖分類號：0657.7 文獻標志碼：A 文章編號：1004—6755（2025）06—0032—05

The influence of the usage time of Liquid Chromatography Column on the detection results of sulfonamides in aquatic Products*

MA Ruixin1，2，ZHANG Pengyan1'2，CAO Junmin1，ZHANG Chunming3 （1.Hebei Aquatic Technology Extension Station，Shijiazhuang O5oo35，China； 2.Hebei Station for Quality Inspectionand Monitoring for Aquatic Products，Shijiazhuang O5oo35，China; Tangshan Municipal Corpsof AgriculturalCoordinated Administrative Law Enforcement，Tangshan O630oo，China）

Abstract：The influence of the use time of Liquid Chromatography Column on the detection data of sulfonamide compounds in aquatic products was tested and compared. The test showed that after the Liquid Chromatography Column was used for a period of time，the retention time of 12 sulfonamides were all reduced and the detection results of Sulfadiazine was decreased significantly owing to the variation of matrix effect，the stability of detection data can be maintained by changing a new Liquid Chromatography Column or changing the mobile phase gradient.

Key words：aquatic products； sulfonamides；Liquid Chromatography Column; retention time；matrix effect

磺胺類化合物是水產(chǎn)養(yǎng)殖中廣泛使用的一類抗菌藥物，殘留限量為 100μg/kg[1] 。（剩余3798字）