術(shù)前中性粒細(xì)胞與淋巴細(xì)胞比值及血小板與淋巴細(xì)胞比值對陰莖癌腹股溝淋巴結(jié)轉(zhuǎn)移的預(yù)測價(jià)值

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[11.山西醫(yī)科大學(xué)第三醫(yī)院（山西白求恩醫(yī)院，山西醫(yī)學(xué)科學(xué)院，同濟(jì)山西醫(yī)院）泌尿外科，山西太原 030032；2.山西醫(yī)科大學(xué)公共衛(wèi)生學(xué)院，山西太原 030001]

Predictive value of preoperative NLR and PLR for inguinal lymph node metastasis of penile cancer

LI Jian1，GUO Wenjing2，SUN Zhongzhong1，WU Jinfeng1

（1. Department of Urology，The Third Hospital of Shanxi Medical University， Shanxi Bethune Hospital， Shanxi Academy of Medical Sciences， Tongji Shanxi Hospital， Taiyuan 030032；2. School of Public Health， Shanxi Medical University， Taiyuan 030001， China）

ABSTRACT：Objective

To explore the value of preoperative neutrophil-to-lymphocyte ratio （NLR） and platelet-to-lymphocyte ratio （PLR） in the prediction of inguinal lymph node metastasis of penile cancer to provide a new idea for the clinical evaluation.

Methods A total of 48 patients with penile cancer who received surgical treatment in our hospital during Jan. 2016 and Dec. 2021 were selected and divided into the metastatic group （n=19） and non-metastatic group （n=29）. The number of neutrophils， lymphocytes and platelets were recorded， and NLR and PLR were calculated. The value of NLR and PLR in predicting inguinal lymph node metastasis was analyzed with receiver operating characteristic （ROC） curve. The correlation between NLR and PLR was determined with Pearson correlation analysis. Results The levels of NLR and PLR were significantly higher in the metastatic group than in the non-metastatic group （P<0.05）. ROC curve showed that the optimal cut-off value of NLR was 2.39， the area under the ROC curve （AUC） was 0.838 （95%CI：0.730-0.947）， with sensitivity of 94.7% and specificity of 58.6%， respectively. The optimal cut-off value of PLR was 113.66， the AUC was 0.755 （95%CI：0.618-0.892）， with sensitivity of 89.5% and specificity of 58.6%， respectively. The AUC of the two combined together was 0.851 （95%CI：0.747-0.956）， with sensitivity of 89.5% and specificity of 69.0%. The Pearson correlation analysis showed that NLR was positively correlated with PLR in patients in both groups （r=0.504， r=0.645， P<0.05）.Conclusion Preoperative NLR and PLR levels are significantly increased in patients with penile cancer，and the combination of the two indexes can predict the possibility of inguinal lymph node metastasis.

KEY WORDS：penile cancer；inguinal lymph node metastasis；inflammatory factor；neutrophis；lymphocytes；platelets

摘要：目的 分析術(shù)前中性粒細(xì)胞與淋巴細(xì)胞比值（NLR）及血小板與淋巴細(xì)胞比值（PLR）對陰莖癌腹股溝淋巴結(jié)轉(zhuǎn)移的預(yù)測價(jià)值，為臨床評估提供新思路。（剩余8063字）