銅調(diào)節(jié)的細(xì)胞死亡相關(guān)基因與前列腺癌關(guān)系分析

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（河南中醫(yī)藥大學(xué)第一附屬醫(yī)院泌尿外科一區(qū)，河南鄭州 450003）

Analysis of the association between copper death-related genes and prostate cancer

LI Wei，CHENG Feng，ZHU Junlei，WANG Suogang

（The First Urology Ward，The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450003，China）

ABSTRACT：

Objective To analyze the association between copper death-related genes and prognosis of prostate cancer and immune cell infiltration based on the cancer genome atlas （TCGA）.Methods The mRNA transcriptome data of all prostate cancer patients were downloaded from TCGA，including 501 prostate cancer tissues and 52 normal tissues.The expression matrix of copper death-related genes was extracted with R software.Differential analysis and multivariate regression analysis were conducted to screen out the prognostic genes，which were then analyzed to explore the correlation between prognosis-related genes and immune cells.Results GCSH gene was significantly correlated with the prognosis of prostate cancer，and significantly

correlated with dendritic cells，CD8+ T cells and plasma cells （P<0.05）.Conclusion GCSH gene plays an important role in the occurrence and development of prostate cancer，and may become a prognostic marker of the disease.

KEY WORDS：prostate cancer；copper-related cell death；

tumor microenvironment；glycine cleavage system protein H；cancer genome atlas；marker

摘要：目的 基于美國(guó)癌癥腫瘤基因圖譜（the cancer genome atlas，TCGA）數(shù)據(jù)庫(kù)分析銅調(diào)節(jié)的細(xì)胞死亡相關(guān)基因與前列腺癌患者預(yù)后和免疫細(xì)胞浸潤(rùn)的關(guān)系。（剩余6569字）