中藥有效成分抗腫瘤作用機(jī)制研究進(jìn)展

Advances on Anti-tumor Action Mechanism of Effective Ingredients of Traditional ChineseMedicine

Jia Zheng1， Zhang Shuang-qing2

（1TangshanVocationaland Technical College，Tangshan O63000;

2 National Institute for Nutritionand Health，Chinese Center forDisease Controland Prevention，Beijing100050）

Abstract： Traditional Chinese medicine has many advantages in the treatment of tumors，such as low adverse reactions and mult-target coordination.Byregulating certain signaling pathways，causing tumor apoptosis，controlling the celldivisioncycle，and inhibiting the binding of PD-1andPD-L1，some traditional Chinese medicines can improve immune cell recognitionof tumors，lessen the negative efectsof chemotherapyandradiation，improve theemotional states of tumorpatients，incuding fatigue，depression，and insomnia，and improve thetherapeutic effectofcancerpain. The combined application of traditional Chinese medicine and surgery，chemoradiotherapy，immunotherapyandother methods willhave more and more broad space.Over the past five years， we have examined the advancements made in the beneficial constituents of single Chinese medicine for the treatment of cancers，and we have included some references for pertinent staff members.

Key words： traditional Chinese medicine;effective ingredient; anticancer effect; signaling pathway;immune checkpoint

中醫(yī)藥用于腫瘤的防治在我國有幾千年的歷史，商代的甲骨文就記載了“瘤”字，經(jīng)典著作《黃帝內(nèi)經(jīng)》中記載了“石疲”“昔瘤”和“癖結(jié)”等多種和腫瘤類似的病種。（剩余16868字）