光蛋白聚糖在鈣化性主動(dòng)脈瓣疾病中的作用機(jī)制與潛在治療靶點(diǎn)的研究進(jìn)展

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TheMechanisms ofLumican in Calcific Aortic Valve Disease and Its Potential Therapeutic Targets

DUAN Qingsong ，HU Houxiang1 （1.DepartmentofCardology，Afiiated Hospitalof North Sichuan Medical College，Nanchong 637o，Sichuan，China； 2.Department of Cardiology，Guangyuan First People’ s Hospital，Guangyuan 6280oo，Sichuan，China）

【Abstract】Calcificaortic valvedisease（CAVD）isa leadingcauseof aorticvalve stenosis.The progressionof CAVD isclosely associatedwitcalpschstoacetiodelgdltioetlye memberof thesallucinechproteglycafmilyasgaeedignifantatetninCAV.isvieummarzesteprs mechanisms of lumican in CAVD and discusses its potential as a therapeutic target.

Keywords】 Calcific aortic valve disease；Lumican；Extracellular matrix remodeling

鈣化性主動(dòng)脈瓣疾?。╟alcific aortic valve disease，CAVD）是老年人群中最為常見(jiàn)的瓣膜性心臟病之一，隨著全球人口老齡化的加劇，CAVD的患病率呈現(xiàn)出逐年上升的趨勢(shì)，目前已成為導(dǎo)致老年人主動(dòng)脈瓣狹窄的主要原因[1]。（剩余11795字）