聯(lián)合檢測血清抗苗勒管激素和維生素D表達(dá)水平 對(duì)多囊卵巢綜合征患者妊娠結(jié)局的預(yù)測價(jià)值

打開文本圖片集

XuJiao'，RaoHongyun2，ChenRul

'DepartmentofGynaecologyandObstetrics，thePeople'sHospitalofHebi，Hebi458O30，China;2Departmentof

ReproductiveMedicine，thePeople'sHospitalofHebi，Hebi458o3o，China

【Abstract】 Objective To explore the predictive value of serum anti-Mullerian hormone （AMH）and vitamin D（VD）levels for pregnancy outcomes in patientswith polycystic ovary syndrome （PCOS）.MethodsA retrospective analysis was conducted on10O cases of clinical data of PCOS patientsadmited to Hebi People's Hospital from March 2O22 to March 2024.Allpatients were treatedwithethinylestradioland cyproterone acetate combined with metformin，and clomiphene citrate was used for ovulation induction in the fourth menstrual cycle. The patients with good pregnancy outcomes （7O cases） were clasified as the good pregnancy outcome group，and those with poor pregnancy outcomes （30 cases）were classified as the adverse pregnancy outcome group.Another 50 non-PCOS women preparing for pregnancy during the same period were selected as the control group.General data， fetal prognosis，serum AMH，and 25-（OH）D levels of the three groups were compared，and the predictive value of AMH and 25-（OH）D alone and in combination was calculated.ResultsThe AMH levels in the good pregnancy outcome group and the adverse pregnancy outcome group were higher thanthose in the control group，while the 25- （OH）D levels were significantly lower than those in the control group （P<0.05） ）.Thereweresignificant differencesin the indicators between the good pregnancy outcome group and the adverse pregnancy outcome group （ P <0.05）. The age and BMI of the good pregnancy outcome group were lower than those of the adverse pregnancy outcome group （ P （20號(hào) <0.05）.Multivariate Coxregressonanalysisshowed that high AMH levelsand low25-（OH）D levelswere independent risk factors for adverse pregnancy outcomes in PCOS patients （P

【Key Words】 Polycystic ovary syndrome;Anti-Mullerian hormone;Vitamin D; Pregnancy outcomeDOI：10.19522/j.cnki.1671-5098.2025.04.012

多囊卵巢綜合征（polycystic ovary syndrome，PCOS）是一種常見內(nèi)分泌疾病，多表現(xiàn)為高雄激素血癥或卵巢多囊樣改變，特征為持續(xù)無排卵或少排卵，是育齡女性不孕原因之二[1-2]。（剩余7270字）