乳腺原發(fā)性腺泡細(xì)胞癌3例臨床病理及文獻(xiàn)復(fù)習(xí)

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【Abstract】 Objective To investigate the clinicopathological features acinic cellcarcinoma the breast， andtoreviewtheliterature toprovidereferencefortheclinicaldiagnosisandtreatmentaciniccellcarcinoma the breast.Methodsclinicopathological data3 patientswithbreastaciniccellcarcinoma diagnosedand treated in People's from January2O23 to July2O24 werereviewed，andtheclinical characteristics and post-treatment folow-upresults the disease were analyzed according to thepathological manifestations and diagnosis and treatment process the patients.Results histological morphology breast acinic cellcarcinoma was diverse，mostlymicroadenoidal，tubularandcyst-likestructuresinfiltrating interstitialgrowth，ndosinophilic secretions could be seen in it，and solid and cord-like structures were seen inone case，and tumorcells were rich in cytoplasm，bichromatic or vacuole-like，with round nucleus and obvious nucleoli.One case was accompanied by multifocalaggregation lymphocytes.Immunophenotype： tumorcels in 3cases were negativefor ERand HER-2，2 cases were PR negative，1 case was PR 20%+ ），α1-antichymotrypsin and lysozyme were diffuse and strong positive in 3 cases，myoepithelial markersand Collagen IV were negative，and the Ki-67 value-added index was 40% ＼～70%.

ConclusionBreastaciniccellcarcinoma gene mutation is highlyoverlapping with triple-negative breast cancer （TNBC），suggesting that breastaciniccell carcinoma may be a more aggressive TNBC precursor.

【Key Words】 Breast neoplasms;Carcinoma，acinar cell； ，clinical; PrognosisDOI：10.19522/j.cnki.1671-5098.2025.04.011

乳腺腺泡細(xì)胞癌（aciniccellcarcinoma）是一種罕見的乳腺原發(fā)惡性腫瘤，根據(jù)第5版世界衛(wèi)生組織（WHO）乳腺腫瘤分類（2019），乳腺腺泡細(xì)胞癌被定義為一種由透明或顆粒狀上皮細(xì)胞組成的惡性上皮性腫瘤，通常為三陰性乳腺癌（TNBC），但與其他TNBC患者比較預(yù)后相對較好[1]。（剩余6246字）