P糖蛋白在不同組織器官中的定位和調(diào)控研究進展

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關(guān)鍵詞：P糖蛋白；分子結(jié)構(gòu)；轉(zhuǎn)運機制；定位；調(diào)控 中圖分類號：Q71文獻標識碼：A 文章編號：1000-503X（2025）02-0295-08 DOI：10.3881/j. issn.1000-503X.16156

Advances in the Localization and Regulation of P- glycoprotein in Different Tissues and Organs

ZHAO Jiahua12，YANG Xiaosa2，XU Xiaojiao12，LIU Rui'，2，ZHUANG Tiantian ， ZHANG Jiatang'

（204號 School of Medicine，Nankai University，Tianjin 300071，China （204號 DepartmentofNeurology，TheFirstMedical Center，ChinesePLAGeneralHospital，Beijing100853，China （20 Graduate School，Medical School of Chinese PLA，Beijing 100853，China Corresponding author：ZHANG JiatangTel：010-55499321，E-mail：zjt1128@aliyun.com

ABSTRACT：P-glycoprotein（P-gp）is an ATP-dependent efflux transporter that is distributed in many tissues and organs.P-gp can selectively pump endogenous substrates and exogenous chemicals from the cellto the outside of the cellto maintain a stable endo-environment.However，it meanwhile restricts the entry of therapeutic drug into tissues and organs，and in particular，mediates the multidrug resistance of tumor cels to chemotherapeutic drugs.Therefore，understanding the localization of P-gp in diferent tissues and organs maybe an important breakthrough point for disease treatment.In this paper，we mainly review the molecular structure，transport mechanism，localization，and regulation of P-gp in diferent tisses and organs，providing reference forthe subsequent treatment of diseases.

Key Words：P-glycoprotein；molecular structure；transport mechanism； localization；regulation

ActaAcadMedSin，2025，47（2）：295-302

細胞毒性抗癌藥物成功應用于癌癥治療的同時，也帶來了藥物不良反應和患者因多藥耐藥（multidrugresistance，MDR）而導致治療失敗的挑戰(zhàn)[1]。（剩余20368字）