運動發(fā)揮抗炎作用改善神經(jīng)炎癥相關(guān)抑郁癥的研究進展

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關(guān)鍵詞：運動；抑郁癥；神經(jīng)炎癥；抗炎；運動處方

中圖分類號：R749.4；G807.4文獻標識碼：A 文章編號：1000-503X（2025）02-0191-07

DOI：10.3881/j. issn.1000-503X.15991

Research Progress in the Anti-Inflammatory Effect of Exercise in Ameliorating Neuroinflammation- Related Depression

ZHANG Zhixin1，2，GUO Qi1，CHEN Xiaoyu Colegeof Rehebilitation Sciences，Shanghai Universityof Medicineand Health Sciences，Shanghai 2O1318，China Tianjin Key Laboratoryof Exercise Physiologyand Sports Medicine，Institute of Sport，Exercise and Health， TianjinUniversityofSport，Tianjin，China

Corresponding author：CHEN Xiaoyu Tel：18822202275，E-mail：1334427886@qq.com

ABSTRACT：Depression is an affective disorder caused by multiple factors，and its pathogenesis is stil unclear.However，in recent years， studies have found an association between neuroinflammation and depression， which is mainlyreflected inthe interaction of their pathogeneses，such as abnormalitiesof monoamine neurotransmiters inthe brain，dysregulation of thehypothalamic-pituitary-adrenal axis，anddysfunction of neurogenesis. Currently，exerciseas a therapy for depression has attracted widespread attntion. By reviewing relevant research reports，this article summarizes that exercise allviates neuroinflammation by playing an anti-inflammatory role， thus improving the mood-related pathway to treat depresion.Furthermore，thisarticle explores theefects of different exercise prescriptions on the anti-inflammatory role of exercise，aiming to provide new scientific ideas for the treatment of depression associated with neuroinflammation.

Key words：exercise；depression；neuroinflammation；anti-inflammatory；exercise prescription

ActaAcadMedSin，2025，47（2）：191-197

抑郁癥是一種最常見的精神疾病，以情緒低落、快感缺失和社交障礙等表現(xiàn)為主。（剩余19111字）