香豆素類(lèi)化合物結(jié)構(gòu)修飾合成及抑菌活性測(cè)定

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摘 要：以取代水楊醛與丙二酸二乙酯為原料，合成中間體3-甲酸乙酯-香豆素衍生物后進(jìn)行酯的堿性水解反應(yīng)，酸化得到反應(yīng)中間體3-甲酸-香豆素衍生物，在此基礎(chǔ)上使用羧酸酰基化催化劑催化活化，進(jìn)行一系列?；〈玫侥繕?biāo)化合物26個(gè)，并測(cè)定目標(biāo)化合物的抑菌活性。結(jié)果表明，部分目標(biāo)化合物抑菌活性效果良好。

關(guān)鍵詞：香豆素；衍生物；合成；抑菌活性

中圖分類(lèi)號(hào)：TQ225.2

文獻(xiàn)標(biāo)志碼：A文章編號(hào)：1001-5922（2023）01-0113-04

Synthesis and antibacterial activity of coumarins

GAO Dongmei1，DU Zhenting2

（1.Yangling Vocational & Technical College，Yangling 712100，Shaanxi China ;

2.Northwest A&F University，Yangling 712100，Shaanxi China

）

Abstract： Using substituted salicylaldehyde and diethyl malonate as raw materials，the basic hydrolysis reaction of esters was carried out after the synthesis of ethyl 3-carboxylate-coumarin derivatives，and the reaction intermediate 3-carboxylic acid-coumarin derivative was obtained by acidification.On this basis， bean derivatives were catalyzed and activated by a carboxylic acid acylation catalyst，and a series of acylation substitutions were carried out to obtain 26 target compounds， and the antibacterial activities of the target compounds were determined.The results showed that some target compounds had good antibacterial activity.

Key words：coumarin;derivatives;synthesis;bacteriostatic activity

香豆素類(lèi)化合物具有α-苯并吡喃酮結(jié)構(gòu)［1］，廣泛存存在于植物、動(dòng)物、微生物及其次生代謝物中。（剩余7024字）