非離子型碘造影劑致患者死亡43例文獻(xiàn)分析

打開文本圖片集

中圖分類號(hào) R981+.1；R969.3 文獻(xiàn)標(biāo)志碼A 文章編號(hào) 1001-0408（2025）13-1655-06

DOI10.6039/j.issn.1001-0408.2025.13.17

Literatureanalysisof43cases of deathcausedbynon-ionic iodinecontrastmedia

TIAN Hongxing，TIAN Hongyan，LI Tao，YAN Wan，LI Yue（Dept. of Pharmacy，Guiyang Maternal and Chilc Health Care Hospital，Guiyang 550003，China）

ABSTRACTOBJECTIVEToanalyze thecharacteristicsandinfluencing factorsof patientdeathscaused bynon-ioniciodine contrastmediaandproviderecommendations forsafemedication，therebyprovidingreferencesforclinicalappication.METHODs Reportsoffatalcasesassociatedwithnon-ioniciodinecontrast mediawereretrieved fromdatabases includingCNKI，Wanfang， VIP，PubMed，CochraneLibrary，Webof Science，Embase，and SpringerLink.Statistical analysis was performed toexamine the characteristicsandinfluencingfactorsofthesefataities.RESULTSAtotalof43deathscausedbynon-ioniciodinecontrastedia were retrieved，including 21 males （ 48.84% ）and22females 51.16% ）.The majority of deaths occurred in 32 patients aged 51-85 years old （74.42%） ）.The original diseases were mostly cardiovascular and cerebrovascular diseases（ 30.23% ）and digestive system diseases（ 30.23% ），and only 2 cases had a clear allergy history（ 4.65% ）.Among the lethal drugs，iohexol（ 37.21% ）and iopromide（ 25.58% ）accounted for the highest proportions. The main causes of death were anaphylactic shock！ （51.16% ），cardiac arrest （11.63% ），and pulmonary edema（ 11.63% ）； 48.84% of the patients’ADR occurred within 30 minutes，and 62.79% of the patients diedonthefirstday.It mainly involvedthecirculatory system，nervoussystem andrespiratorysystem，andthemain manifestations were breathingdificulties，loworundetectablebloodpressure，vomiting，etc.CONCLUSIONSThelethaldrugsof non-ioniciodinecontrastmediaaremainlyiohexolandiopromide.Theadversereactionsocrquickly.Clinically，itisnearyto focusonmonitoringthevitalsignswithin 3Ominutesaftermedication，andtimelytreatmentof symptomssuchas dyspneaand abnormal blood pressure to reduce the risk of death.

KEYWORDSnon-ionic iodine contrast media；death；literature analysis；adverse drug reaction

隨著醫(yī)學(xué)影像技術(shù)的快速發(fā)展，含碘造影劑已被廣泛應(yīng)用于計(jì)算機(jī)斷層掃描（computed tomography，CT）、冠脈造影及尿路造影等領(lǐng)域。（剩余10594字）