生活方式干預(yù)對(duì)心血管代謝性共病病人影響的Meta分析

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Influence of lifestyle intervention on patients with cardiovascular multimorbidity：a Meta-analysis ZENG Jinghui'，SONG Kai'，LI Na1，ZHANG Jing1，YANG Longhui'，ZHU Ruifang1，2*

1.Schoolof Nursing，Shanxi Medical University，Shanxi O3ooo1China；2.FirstHospitalofShanxiMedicalUniversity *Corresponding Author ZHU Ruifang，E-mail： ruifang.zhu@ sxmu.edu.cn

AbstractObjective：Tosystematicallevaluatetheimpactoflifestyleinterventionsonvariousindicatorsofmetabolicsyndromein patientswithardiometabolicultimorbidityndtoprovideevdencebasedisightsfoiseasepreventionintispopulationetos： Randomizedcontroledtrials（RCTs）relatedtocardiometabolicultimorbidityandlifestyleinterventionswereretrievedfromdatabases includingCNKI，WanFangDatabase，VIP，PubMed，theCochrane Library，WebofScience，andEMbase.Thesearchperiodspaned fromJanuary4，tptebr2otalltearrsiepedentlyuctedliatureeigdtaecid riskofbiasassessment.Meta-analysiswasperformedusingRevMan5.4.1software.Results：Atotalof18articles wereincluded.It involved1596patients.Metaanalysisresultsdemonstratedthatlifestyleinterventionssignificantlyimprovedhig-densitylipoprotein choesterol （HDL-C）（WMD=0.10， 95% C10.00 ）-0.20，P=0.04） ，fasting blood glucose （FBG）（WM） （204號(hào) P=0.001 ，triglycerides（TG）（WMD= -0.48 ， 95% CI -0.73--0.24 ），systolic blood pressure （SBP） （WMD ， 95% CI -12.06-3.39 ， P=0.000 5），and waist circumference （WC）） （WMD ， 95% CI -6.16--0.24 P=0.03 ）.Subgroup analysisevealedthatlifestyleinterventioslasting morethan3monthssignificantlyimproedHD-C，F(xiàn)BG，G，BP，andWleels inpatients with cardiometabolic multimorbidity，with statistically significant differences ΔP<0.05 ）.Conclusions：Current evidence sugeststhatlifestyleinterventionscanefectivelyimprovemetabolicsyndrome-relatedindicatorsinpatientswithcardiometabolic multimorbidityingdatagesuchsideectsiplicityndosiveess.owerefcacyofetio lasting less than 3 months requires further validation.

Keywordslifestyle；cardiometabolic multimorbidity；metabolic syndrome； Meta-analysis； evidence-based nursing

心血管代謝性共病（cardiometabolic multimorbidity，CMM是指個(gè)體同時(shí)存在2種及以上的心血管代謝性疾病（cardiometabolicdiseases，CMD），包括但不限于糖代謝疾?。?型糖尿病或糖調(diào)節(jié)受損）、腦卒中、脂代謝疾?。ǜ吣懝檀佳Y或高三酯甘油血癥）冠心病、原發(fā)性高血壓等[1]。（剩余11885字）