封閉劑與氟保護(hù)漆預(yù)防兒童第一恒磨牙咬合面齲的Meta分析

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[Abstract]ObjectiveTo assessthe effectiveness of the comparison between pit and fissure sealantsand fluoride varnishes，as wellasvarious types ofsealantsin preventingcariesontheoccusalsurfaceofchildren’sfirstpermanentmolars （FPM）.MethodsConduct acomprehensive search ofliteraturepublished between January1，1988，and May30， 2024，inthe following databases： China National Knowledge Infrastructure，WebofScience，CochraneLibrary，Embase， PubMed，China SciencePeriodical Database and China Biology Medicine database.Meta-analysis and subgroup analyses were performedonthe literature that metthe inclusioncriteria.ResultsAtotalof5618pieces ofliterature wereretrieved，resultingintheinclusionof14inthestudy.Meta-analysisshowedthattherewasnostatisticallsignificantdifferencein the efficacybetweenvaries pit and fissure sealants compared to fluoride varnishes，and between varies types

ofsealantsin preventing caries on the occlusal surface of children’sfirstpermanentmolarswithin24monthspostsurgery （P>0.05） .Conclusion Within24months，there wasno significantdifference in the effectiveness ofusing

resin-basedorglassiomomer pitand fissure sealants compared withfluoride varnishes in preventing occlusalcaries in FPMinchildren;within24 months，there was no significant difference intheefectivenessofusingresin-based sealants compared with ARTsealants in preventing occlusalcaries inFPM inchildren.ARTsealants are recommended over resinbased sealers for children who have no conditions for chair-side manipulation or who are poorly co-operative.

[Key Words]pit and fissure sealant;fluoride varnish；first permanent molar;caries prevention;Meta-analysis

第一恒磨牙（firstpermanentmolar，F(xiàn)PM）通常在兒童6歲左右萌出，由于萌出時(shí)間較早且存在較深的點(diǎn)隙窩溝，最易罹患齲病[]。（剩余12820字）