口腔潛在惡性病變的臨床病理學(xué)診斷研究進(jìn)展

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[中圖分類號(hào)] R780.2 [文獻(xiàn)標(biāo)志碼] A [doi] 10.7518/hxkq.2025.2024427

[Abstract]Asthefieldoforal pathologyhasevolved，thenomenclatureand clasificationoforalmucosaldiseases witha remarkable riskof malignant transformation have undergoneseveral modifications.In 2oo5，the WorldHealth Or

ganization （WHO） introduced the concept of oral potentiallymalignant disorders（OPMDs）asan alternative to theterms fororal precancerouslesionsand precancerous conditions.In the consensusreport by theWHO CollaboratingCenterforOralCancerof2021，OPMDisdefined as“anyoral mucosal abnormalitythatisassociatedwith astatistically increased risk of developing oral cancer.” This definition encompasses a range of conditions， in

cludingoral leukoplakia，oral submucous fibrosis，proliferative verrucous leukoplakia，oralichenplanus，andotherlesions.Inlightoftecomplexetiologyunclearpathogenesis，andcarcinogenesisofOPDs，earlyandprecisediagosis andtreatmentcancontribute tothe secondary prevention oforalcancer.For this reason，thisreview，whichaims toprovidea basis forthe precise clinical diagnosisofOPMDs，was performed.Itsaim wasachieved byreviewing thehistorical evolutionandresearch progressofthe nomenclature，clasification，and histopathological diagnosticcriteriaofOPMDs.

[Keywords]oralpotentiallymalignant disorders；oral leukoplakia；oral submucous fibrosis；proliferative verrucous leukoplakia；oral lichen planus

自1805年首次提出“癌前病變”這一概念以來，它一直指的是那些在長(zhǎng)期觀察中可能演變?yōu)閻盒阅[瘤的良性疾病。（剩余18300字）