光聲遙感彈性成像檢測支氣管纖維化生物力學(xué)特性

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中圖分類號：0436 文獻(xiàn)標(biāo)志碼：A DOI：10.3969/j.issn.1007-7146.2025.03.006

Abstract：Obstructivebronchitis isafibrotic diseaseofthelungs thatoccurs inresponse to inhalationofnoxious gases， immune dysfunctionandlungorbone marrowtransplantation.Fibrosisisapathologicalhallmarkofobstructivebronchiis，nd alterations initsmechanicalpropertiesplayakeyroleinunderstandingthepathologicalprogressionofobstructivebronchitis. Duetothelackofstudiesrelatedtothemechanical propertiesofobstructivebronchitis，litleisknownabout thepathological mechanismsinthisarea.Therefore，inthispaper，toadresstheaboveproblem，photoacousticremotesensingelastographywas usedtoimagethebiomechanicalpropertiesofbronchialfibrosis.Theresultsshowedthattherisetimesofphotoacousticsignals correspondingtonormalbronchialtubesaswellasbronchialtubesintheearlymiddle，ndlatestagesoffibrosis were113ns， 107ns，96nsand7Onsespectielyndasortrisetieresultedinalargeelasticmodulus;theelasticmodusootic bronchialubes waslarger thanthatofnormalbronchialtubes，andtheelastic modulus inthethreestagesoffibrosisincreased sequentiall fromtheearlystage tothelate stage.Inthis paper，thechangesofbronchial mechanical properties during the processofobstructive bronchitis were investigatedandtherelativevaluesofelastic modulus were extractedtoproposea new reference for the graded diagnosis and prevention of obstructive bronchitis.

Key words： biological optics; photoacoustic imaging; elastic imaging; photoacoustic remote sensing; bronchial fibrosis

（ActaLaser BiologySinica，2025，34（3）：239-245）

閉塞性支氣管炎（bronchiolitisobliterans，BO）是一種以小氣道狹窄和阻塞為特征的纖維化肺部疾病[1]，最常見于肺移植或骨髓移植的患者，但也有患者因職業(yè)原因暴露于活性揮發(fā)性化學(xué)物質(zhì)而發(fā)病。（剩余11366字）