白細(xì)胞介素-22在炎癥性腸病中的研究進(jìn)展

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Advances inResearch on Interleukin-22in Inflammatory Bowel DiseaseCAO Kejing'，CHEN Yingwei22. 'DepartmentofGastroenterology，XinuaHospitalAfliatedtonghaiJiaoTongUniversityShoolofedicine，nghai ; 2Shanghai Key Laboratory ofPediatricGastroenterologyandNutrition，Shanghai

Correspondence to： CHEN Yingwei， Email： chenyingwei@xinhuamed.com.cn

AbstractInflammatorybowel disease（IBD）isachronicrelapsing inflammatorydisorderof thegastrointestinal tract. Interleukin（IL）-22，amemberoftheIL-1Ocytokiefamily，playsacriticalroleinprotectingtheitestinalepithelialbr andmaintaining gut homeostasis.Multiple studies indicate that IL-22can induce inflammationandpromote the inflammation-cancertransformationinBDunderdiferentconditions.Aditionaly，IL-22isintricatelyinvoledithe developmentand progressionofcolorectalcancer （CRC），positioning itasa promising therapeutic targetforanti-cancer interventions.Thisarticle reviewed the advancesin research onIL-22in IBD.

KeyWordsInterleukin-22；Inflammatory Bowel Disease;Colorectal Neoplasms

炎癥性腸?。╥nflammatoryboweldisease，IBD）是由個體遺傳易感性催化的對腸道微生物異常持續(xù)免疫反應(yīng)引起的慢性復(fù)發(fā)性胃腸道炎性疾病，包括克羅恩?。–rohn'sdisease，CD）和潰瘍性結(jié)腸炎（ulcerativecolitis，UC）。（剩余18516字）