頭孢妥侖匹酯關(guān)鍵雜質(zhì)的合成

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中圖分類號(hào)：R978 文獻(xiàn)標(biāo)識(shí)碼：A 文章編號(hào)：1001-8751（2025）02-0140-05

SynthesisoftheKeyImpurityofCefditoren Pivoxil

Zhou Jun-rong （Zhejiang DongbangPharmaceutical Co.，Ltd， Linhai Zhejiang ）

Abstract： ObjectiveStudy the synthesis method of key impurities incefotentin axetil.MethodsCefditoren pivoxil was used as the starting material.Then cefditoren pivoxil and chloro（methoxy） methane or iodomethyl pivalate was subjected to a condensation reaction to synthesize methoxymethyl cefditoren pivoxil or cefditoren dipivoxil. ResultThepurityof the products was relatively high.Additionally，it wassimple tocollect the basic ingredients needed for this method. ConclusionThe correctnessof the chemical structure of methoxymethyl cefditoren pivoxil and cefditoren dipivoxil was confirmed by IR， HR-MS and NMR.

Key words： cefditoren pivoxil；；synthesize；methoxymethyl cefditoren pivoxil； cefditoren dipivoxil； chemical structure

頭孢妥侖匹酯屬于第三代頭孢菌素類口服抗生素，原研廠家為日本明治制果株式會(huì)社，國(guó)內(nèi)僅原研口服（片劑與顆粒劑）制劑獲批上市，商品名稱為美愛克，市場(chǎng)潛力巨大。（剩余7757字）