PTX3調節(jié)膠質瘤TMZ耐藥的研究進展

【中圖分類號】 R739.41 【文獻標志碼】 A 【文章編號】 1672-7770（2025）03-0330-05

Abstract：Glioblastoma（GBM）isone of the most aggressive and lethal malignancies within thecentral nervous system，with therapeuticeffcacyoften limited bythedevelopmentofresistance.Temozolomide（TMZ）isthe cornerstonechemotherapeuticagentin the standard treatment regimen for GBM.However，the emergenceof TMZ resistance significantlyimpactspatient survival outcomes.Inrecent years，Pentraxin 3（PTX3），akeyregulatory factorwithinthe tumormicroenvironment（TME），has garneredwidespreadatentionforitsrole inthedevelopmentof resistance in GBM.PTX3not only promotes tumor survival and invasion by modulating immunecell polarization， redox balance，and the inhibitionof autophagy withinthe TME，butalso enhancetheresistanceof tumor cells to TMZ through interactions with multiple cellarsignaling pathways.This review discusss thespecificroleof PTX3 in the mechanisms of GBMresistance and explores its potential asa therapeutic target，aiming to provide new strategies and insights for overcoming GBM resistance.

Key words：glioblastoma；Pentraxin 3；tumor microenvironment；resistance mechanisms；redox balance; ：egulation of autophagy inhibition

膠質瘤是中樞神經系統(tǒng)中最具侵襲性和致命性的惡性腫瘤之一，起源于腦或脊髓中的膠質細胞。（剩余13692字）