育齡期女性垂體催乳素腺瘤手術(shù)療效及預(yù)后預(yù)測模型研究

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關(guān)鍵詞】育齡期女性；垂體催乳素腺瘤；經(jīng)蝶手術(shù)；生化緩解；列線圖 【中圖分類號(hào)】 R651.1+3 【文獻(xiàn)標(biāo)志碼】 A 【文章編號(hào)】1672-7770（2025）03-0291-07

Abstract：ObjectiveTo study the influencing factors of biochemical remission after neuroendoscopic transsphenoidal resection of prolactin adenoma in female patientsof reproductive age and to construct a relevant prediction model. MethodsThe clinical data of 232 patients underwent transsphenoidal prolactin adenoma resection in the Department of Neurosurgery，the Affiliated Hospital of Xuzhou Medical University from January 2O15 to May 2O23 were retrospectively analyzed，and they were randomly divided into a training group and a validation group according to the ratio of 7：3. Independent risk factors affecting biochemical remission after surgery were screened using unifactorial and multifactorial analyses and included in the prediction model. ResultsThe patients’ body mass index（BMI），preoperative Knosp classification of pituitary tumors， postoperative prolactinvalue on the first day，and Ki-67 were the independent risk factorsaffecting the patients' postoperative biochemical remisson. The area under the ROC curve of the prediction model built in this way was O.85 and O.94 in the training and validation sets，respectively，and was wellcalibrated and clinically useful. ConclusionsIn this study，a prediction model affecting biochemical remission after neuroendoscopic transsphenoidal prolactin adenoma resection was constructed by multifactorial analysis，which has good clinical utility and can provide clinical reference value for the selection of treatment options for female prolactin adenoma patients in reproductive age.

Key words：female of childbearingage；prolactinadenoma；transepithelial surgery; biochemical remission ； columnar line drawing

垂體腺瘤（pituitaryadenoma，PA）是臨床常見的顱內(nèi)原發(fā)性腫瘤，其在顱內(nèi)腫瘤的發(fā)病率約為15% ，僅次于神經(jīng)上皮源性腫瘤和腦膜瘤[1]。（剩余10795字）