原發(fā)性Meige綜合征不同靶點腦深部電刺激療效比較

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【中圖分類號】 R651 【文獻標(biāo)志碼】 A 【文章編號】 1672-7770（2025）03-0263-09

Abstract： ObjectiveTo compare the eficacy deep brain stimulation（DBS） with different targets in primary Meige syndrome（PMS）.MethodsThe clinical data 15 patients with PMS underwent DBS treatment targeting diferent sites in the University fromApril 2021 to June 2024 were analyzed retrospectively. The 15 patients with PMS received bilateral subthalamic nucleus（STN） or globus pallidus internus（GPi） DBS surgery. The Burke-Fahn-Marsden Dystonia Rating Scale（BFMDRS） （including motor and disability subscale），Hamilton Anxiety Scale（HAMA），and Hamilton Depression Scale（HAMD）were uniformly used to evaluate and record the preoperative and postoperative muscle tone，limb motor function，and mental status the enrolled patients，as well as to document the related postoperative complications.ResultsThe average improvement rate BFMDRS was 59.23% in15 patients at 3 months after surgery，and 67.87% in 10 patients at 12 months after surgery， respectively. The average improvement rates motor scores between patients who received GPi stimulation and STN stimulation were 65.80% and 71.70% ，respectively，and the stimulation the two targets could effctively improve the symptoms，but without statistical difference（ P>0.05 ）.The scores HAMA scale and HAMD scale were improved to different extent compared with those before operation，and the improvement rate HAMA scale in the STN group was better than that in the GPi group with statistical significance（ P<0.05 ）． Conclusions Both DBS targets are safe and eective in improving motor symptoms in patients with Meige syndrome，and there is no significant diffrence between two DBS targets for symptom improvement， and STN-DBS and anxiety symptoms improved better than GPi-DBS.

Key words： Meige syndrome; globus pallidus internus； subthalamic nucleus； deep brainstimulation；anxiety；depression

原發(fā)性 Meige 綜合征（primary Meige syndrome，PMS）是一種成人發(fā)病的節(jié)段性肌張力障礙，其特征為不同程度的眼瞼痙攣和口面頸肌張力障礙，可伴有下面部肌肉、口、舌、咽和頸部肌肉的復(fù)雜運動，包括雙眼眼瞼痙攣（blepharospasm，BSP）和口下頜肌張力障礙（oromandibular dystonia，OMD）[1]。（剩余13230字）