不同給藥途徑下替羅非班聯合阿托伐他汀對冠心病患者PCI術后抗血小板療效及血管內皮功能的影響

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[中圖分類號]R541.4[文獻標志碼]A [文章編號] 2097-5716（2025）03-0386-04

DOI： 10.13308/j.issn.2097-5716.2025.03.014

Influence of tirofiban combined with atorvastatin via different administration routes on antiplatelet efficacy and vascular endothelial function in patients with coronary artery disease after percutaneous coronary interventionGUO Donghai’，LIU Xiaomei，PAN Jianjun2（1. Department of Geriatrics，2. Department of Interventional Radiology，the Fourth People's Hospital of Shangqiu，Shangqiu Henan 4760Oo，China）

[Abstract]ObjectiveTo explore the influence of tirofiban combined with atorvastatin via difrent administration routes on the eficacy and vascular endothelial function of patients with coronary heart disease （CHD）after percutaneous coronary intervention（PCI）.MethodsThe clinical data of 13O patients with CHD were retrospectively analyzed，and they were divided into an intravenous administration group（62 cases） and an intracoronary administrationgroup（68 cases）according to the tirofiban administration route.Cardiac function indexes such as LVEF，LVEDD and LVESD，postoperative TIMI blood flow grading，vascular endothelial function indexes including ET-1 and NO，as wellas the occurrence of adverse reactions such as intracranial hemorrhage， exudative hemorrhage and thrombocytopenia were compared between the two groups.ResultsAfter operation， LVEF，LVEDD and LVESD in the intracoronary administration group were significantly beter than those in the intravenous administration group （all P<0.01 ）. TIMI blood flow grading，and vascular endothelial function indexes such as ET-1 andNO were also significantly beter than those in the intravenous administration group（ll P< 0.01）.There was no statistically significant difference in theoccurrence of adverse reactions between the two groups （ P>0.05 ）.ConclusionIntracoronary administration of tirofiban combined with atorvastatin therapy demonstrates superior eficacy in improving antiplatelet effects andvascular endothelial function in CHD patients after PCI.

[Key words]administration route；coronary artery；vein； tirofiban；atorvastatin；percutaneous coronary intervention；coronary heart disease

冠心病的核心致病機制涉及冠狀動脈（簡稱冠脈）壁的粥樣硬化病理過程，這一過程致使血管內徑變窄乃至閉塞，最終造成心肌血液供應不足，心肌處于缺氧狀態(tài)，導致心肌細胞受損與死亡[1]。（剩余5435字）