腸道菌群及其代謝物在慢加急性肝衰竭發(fā)生發(fā)展中的作用

摘要：慢加急性肝衰竭（ACLF）病情兇險(xiǎn)，發(fā)病迅速，短期病死率高。腸道菌群及其代謝物與ACLF發(fā)生發(fā)展和發(fā)病機(jī)制之間密切相關(guān)。ACLF進(jìn)展過程中，腸道完整性破壞，腸道微生態(tài)及其代謝物失調(diào)，介導(dǎo)免疫紊亂，進(jìn)而加重全身炎癥性反應(yīng)。本文旨在闡明腸道菌群及其代謝物在ACLF發(fā)展過程中的作用和相關(guān)治療策略。

關(guān)鍵詞：胃腸道微生物組；代謝；慢加急性肝功能衰竭

基金項(xiàng)目：國家中醫(yī)藥管理局高水平中醫(yī)藥重點(diǎn)學(xué)科建設(shè)項(xiàng)目（zyyzdxk-2023005）；首都衛(wèi)生發(fā)展科研專項(xiàng)（首發(fā)2024-1-2173）；第七批全國老中醫(yī)藥專家學(xué)術(shù)經(jīng)驗(yàn)繼承工作；北京中醫(yī)藥科技發(fā)展資金項(xiàng)目（BJZYYB-2023-06）；北京市自然科學(xué)基金面上項(xiàng)目（7232272）

Effect of intestinal flora and metabolites on the development and progression of acute-on-chronic liver failure

SHI Ke，ZHANG Qun，WANG Xianbo，F(xiàn)ENG Ying

Center of Integrative Medicine，Beijing Ditan Hospital，Capital Medical University，Beijing 100015，China

Corresponding author：WANG Xianbo，wangxianbo638@163.com （ORCID：0000-0002-3593-5741）

Abstract：Acute-on-chronic liver failure （ACLF） is a dangerous disease with severe conditions，rapid progression，and high short-term mortality. Intestinal flora and metabolites are closely associated with the development，progression，and pathogenesis of ACLF. During the development of ACLF，the destruction of intestinal integrity and the dysregulation of intestinal microecology and its metabolites mediate immune disturbance and thus aggravate systemic inflammatory response. This article elaborates on the role of intestinal flora and metabolites in the development and progression of ACLF and related therapeutic strategies.

Key words：Gastrointestinal Microbiome；Metabolism；Acute-On-Chronic Liver Failure

Research funding：Construction Project of High-level Key Disciplines of Traditional Chinese Medicine of National Administration of Traditional Chinese Medicine （zyyzdxk-202300）；Capital’s Funds for Health mprovement and Research （CFH2024-1-2173）；Seventh Batch of National Traditional Chinese Medicine Experts Academic Experience Inheritance Program；Beijing Traditional Chinese Medicine Technology Development Fund Project （BJZYYB-2023-06）；Beijing Municipal Natural Science Foundation （7232272）

慢加急性肝衰竭（acute-on-chronic liver failure，ACLF）是在慢性肝病基礎(chǔ)上，多種急性打擊導(dǎo)致的肝功能急性嚴(yán)重受損，短期內(nèi)可出現(xiàn)多器官功能衰竭［1］。（剩余18208字）