肝內(nèi)膽管癌精準(zhǔn)檢測(cè)專家共識(shí)（2024版）

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摘要：肝內(nèi)膽管癌（ICC）是一種高度異質(zhì)性的腫瘤，分子分型是實(shí)施ICC個(gè)體化治療的基礎(chǔ)。正確的檢測(cè)方法對(duì)于全面篩選適用靶向藥物的患者群體具有重要的臨床意義。本共識(shí)基于國(guó)內(nèi)外臨床實(shí)踐數(shù)據(jù)，并結(jié)合中國(guó)國(guó)情，圍繞ICC重要靶點(diǎn)進(jìn)行制定，提出了15條推薦意見(jiàn)，以期為ICC的精準(zhǔn)檢測(cè)提供參考。

關(guān)鍵詞：肝內(nèi)膽管癌；精準(zhǔn)檢測(cè)；生物標(biāo)志物；個(gè)體化治療

基金項(xiàng)目：上海市科學(xué)技術(shù)委員會(huì)項(xiàng)目（22JC1403002）

Expert consensus on precision detection of intrahepatic cholangiocarcinoma （2024 edition）

Pathology Group，Chinese Society of Liver Cancer of Chinese Anti-Cancer Association；Liver Pathology Group，Chinese Society of Pathology of Chinese Anti-Cancer Association；Tumor Pathology Committee of Shanghai Anti-Cancer Association，Shanghai200032，China

Corresponding authors：LI Zengshan，Zengshanli@qq.com；CONG Wenming，wmcong@smmu.edu.cn；JI Yuan，ji.yuan@zs-hospital.sh.cn

Abstract：Intrahepatic cholangiocarcinoma （ICC） is a highly heterogeneous tumor，and molecular profiling serves as the foundation for personalized treatment of ICC. Accurate detection methods are clinically significant for comprehensively screening patients suitable for targeted therapies. This consensus is based on clinical practice data from both domestic and international sources，tailored to the Chinese context，and focuses on key targets for ICC. We present 15 recommendations aimed at guiding the precision detection of ICC.

Key words：Intrahepatic Cholangiocarcinoma；Precision Detection；Biomarkers；Personalized Treatment

Research funding：Science and Technology Commission of Shanghai Municipality （22JC1403002）

肝內(nèi)膽管癌（intrahepatic cholangiocarcinoma，ICC）是一種高度侵襲性肝內(nèi)膽管上皮性腫瘤，占肝臟原發(fā)惡性腫瘤的8.2%～15.0%，僅次于肝細(xì)胞癌［1-2］。（剩余15591字）